Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | COLO 858 | 2.0000 | uM | 24 | hr | | Ki-67 | 772.11 | p-Rb(S807/S811) | 44.73 | p-cJun(S73) | 66.84 | 1 | Colo858-signal3 | B3 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.1280 | uM | 24 | hr | | Ki-67 | 779.71 | p-Rb(S807/S811) | 58.29 | p-cJun(S73) | 34.35 | 2 | WM115-signal3 | G6 |
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | Ki-67 | 780.27 | p-Rb(S807/S811) | 73.45 | p-cJun(S73) | 43.18 | 1 | WM115-signal3 | D9 | |
| Vemurafenib | WM-115 | 0.0205 | uM | 24 | hr | | Ki-67 | 780.78 | p-Rb(S807/S811) | 72.14 | p-cJun(S73) | 50.93 | 1 | WM115-signal3 | B8 | |
| JNK-IN-8 | WM-115 | 0.0512 | uM | 24 | hr | | Ki-67 | 781.07 | p-Rb(S807/S811) | 77.07 | p-cJun(S73) | 34.92 | 1 | WM115-signal3 | D7 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0082 | uM | 24 | hr | | Ki-67 | 782.06 | p-Rb(S807/S811) | 76.06 | p-cJun(S73) | 46.14 | 1 | WM115-signal3 | F9 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 782.51 | p-Rb(S807/S811) | 75.83 | p-cJun(S73) | 51.58 | 1 | WM115-signal3 | F11 |
| Vemurafenib | COLO 858 | 2.0000 | uM | 24 | hr | | Ki-67 | 782.90 | p-Rb(S807/S811) | 45.43 | p-cJun(S73) | 59.46 | 2 | Colo858-signal3 | C3 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.1280 | uM | 24 | hr | | Ki-67 | 783.22 | p-Rb(S807/S811) | 57.39 | p-cJun(S73) | 35.93 | 1 | WM115-signal3 | F6 |
| JNK-IN-8 | WM-115 | 0.0033 | uM | 24 | hr | | Ki-67 | 783.34 | p-Rb(S807/S811) | 75.14 | p-cJun(S73) | 46.08 | 1 | WM115-signal3 | D10 | |
| Vemurafenib | WM-115 | 0.1280 | uM | 24 | hr | | Ki-67 | 784.48 | p-Rb(S807/S811) | 55.88 | p-cJun(S73) | 67.92 | 1 | WM115-signal3 | B6 | |
| JNK-IN-8 | WM-115 | 0.3200 | uM | 24 | hr | | Ki-67 | 785.96 | p-Rb(S807/S811) | 71.52 | p-cJun(S73) | 21.74 | 2 | WM115-signal3 | E5 | |
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | Ki-67 | 787.98 | p-Rb(S807/S811) | 73.62 | p-cJun(S73) | 42.75 | 2 | WM115-signal3 | E9 | |
| Vemurafenib | WM-115 | 0.0082 | uM | 24 | hr | | Ki-67 | 788.63 | p-Rb(S807/S811) | 73.58 | p-cJun(S73) | 49.70 | 1 | WM115-signal3 | B9 | |
| JNK-IN-8 | WM-115 | 2.0000 | uM | 24 | hr | | Ki-67 | 790.07 | p-Rb(S807/S811) | 77.44 | p-cJun(S73) | 19.89 | 1 | WM115-signal3 | D3 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | Ki-67 | 795.90 | p-Rb(S807/S811) | 74.91 | p-cJun(S73) | 44.16 | 1 | WM115-signal3 | F8 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | Ki-67 | 796.29 | p-Rb(S807/S811) | 74.93 | p-cJun(S73) | 42.86 | 2 | WM115-signal3 | G8 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | Ki-67 | 797.23 | p-Rb(S807/S811) | 51.78 | p-cJun(S73) | 20.45 | 1 | Colo858-signal3 | F5 |
| JNK-IN-8 | WM-115 | 0.0205 | uM | 24 | hr | | Ki-67 | 798.51 | p-Rb(S807/S811) | 76.68 | p-cJun(S73) | 41.54 | 2 | WM115-signal3 | E8 | |
| JNK-IN-8 | WM-115 | 0.8000 | uM | 24 | hr | | Ki-67 | 800.51 | p-Rb(S807/S811) | 84.77 | p-cJun(S73) | 21.81 | 2 | WM115-signal3 | E4 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | Ki-67 | 801.31 | p-Rb(S807/S811) | 74.66 | p-cJun(S73) | 48.32 | 1 | WM115-signal3 | F10 |
| Vemurafenib | COLO 858 | 5.0000 | uM | 24 | hr | | Ki-67 | 801.46 | p-Rb(S807/S811) | 44.01 | p-cJun(S73) | 45.24 | 1 | Colo858-signal3 | B2 | |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | Ki-67 | 807.26 | p-Rb(S807/S811) | 48.49 | p-cJun(S73) | 14.54 | 1 | Colo858-signal3 | F4 |
| JNK-IN-8 | WM-115 | 5.0000 | uM | 24 | hr | | Ki-67 | 808.69 | p-Rb(S807/S811) | 76.27 | p-cJun(S73) | 22.54 | 2 | WM115-signal3 | E2 | |
| JNK-IN-8 | WM-115 | 0.8000 | uM | 24 | hr | | Ki-67 | 812.54 | p-Rb(S807/S811) | 82.01 | p-cJun(S73) | 21.32 | 1 | WM115-signal3 | D4 |