Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0033 | uM | 24 | hr | | Ki-67 | 2882.90 | p-Rb(S807/S811) | 203.40 | p-cJun(S73) | 97.65 | 1 | LOXIMVI-signal3 | F10 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 3032.30 | p-Rb(S807/S811) | 209.50 | p-cJun(S73) | 127.94 | 1 | LOXIMVI-signal3 | F11 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 5.0000 | uM | 24 | hr | | Ki-67 | 2814.00 | p-Rb(S807/S811) | 96.96 | p-cJun(S73) | 30.63 | 1 | LOXIMVI-signal3 | F2 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 2.0000 | uM | 24 | hr | | Ki-67 | 2379.60 | p-Rb(S807/S811) | 93.92 | p-cJun(S73) | 26.61 | 1 | LOXIMVI-signal3 | F3 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.8000 | uM | 24 | hr | | Ki-67 | 2249.30 | p-Rb(S807/S811) | 93.65 | p-cJun(S73) | 24.47 | 1 | LOXIMVI-signal3 | F4 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.3200 | uM | 24 | hr | | Ki-67 | 2320.10 | p-Rb(S807/S811) | 113.12 | p-cJun(S73) | 29.40 | 1 | LOXIMVI-signal3 | F5 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.1280 | uM | 24 | hr | | Ki-67 | 2553.90 | p-Rb(S807/S811) | 157.20 | p-cJun(S73) | 41.82 | 1 | LOXIMVI-signal3 | F6 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0512 | uM | 24 | hr | | Ki-67 | 2628.70 | p-Rb(S807/S811) | 180.11 | p-cJun(S73) | 54.15 | 1 | LOXIMVI-signal3 | F7 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0205 | uM | 24 | hr | | Ki-67 | 2734.80 | p-Rb(S807/S811) | 188.75 | p-cJun(S73) | 65.47 | 1 | LOXIMVI-signal3 | F8 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0082 | uM | 24 | hr | | Ki-67 | 2742.00 | p-Rb(S807/S811) | 188.71 | p-cJun(S73) | 92.00 | 1 | LOXIMVI-signal3 | F9 |
| JNK-IN-8 | WM1552C | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 236.28 | p-Rb(S807/S811) | 113.21 | p-S6(S235/S236 | 450.52 | 1 | WM1552C-signal2 | D2 | |
| JNK-IN-8 | WM1552C | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 226.81 | p-Rb(S807/S811) | 116.31 | p-S6(S235/S236 | 435.53 | 1 | WM1552C-signal2 | D3 | |
| JNK-IN-8 | WM1552C | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 262.28 | p-Rb(S807/S811) | 113.37 | p-S6(S235/S236 | 413.92 | 1 | WM1552C-signal2 | D4 | |
| JNK-IN-8 | WM1552C | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 249.08 | p-Rb(S807/S811) | 114.01 | p-S6(S235/S236 | 401.71 | 1 | WM1552C-signal2 | D5 | |
| JNK-IN-8 | WM1552C | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 221.29 | p-Rb(S807/S811) | 114.21 | p-S6(S235/S236 | 384.84 | 1 | WM1552C-signal2 | D6 | |
| JNK-IN-8 | WM1552C | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 173.20 | p-Rb(S807/S811) | 108.20 | p-S6(S235/S236 | 395.04 | 1 | WM1552C-signal2 | D7 | |
| JNK-IN-8 | WM1552C | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 244.72 | p-Rb(S807/S811) | 115.35 | p-S6(S235/S236 | 425.96 | 1 | WM1552C-signal2 | D8 | |
| JNK-IN-8 | WM1552C | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 184.24 | p-Rb(S807/S811) | 113.51 | p-S6(S235/S236 | 409.57 | 1 | WM1552C-signal2 | D9 | |
| Vemurafenib | COLO 858 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 452.40 | p-Rb(S807/S811) | 159.51 | p-ERK(T202/Y204) | 579.26 | 1 | Colo858-signal1 | B10 | |
| Vemurafenib | WM1552C | 0.0033 | uM | 24 | hr | | p27 Kip1 | 246.89 | p-Rb(S807/S811) | 106.93 | p-ERK(T202/Y204) | 243.94 | 1 | WM1552C-signal1 | B10 |