Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM-115 | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 241.43 | p-Rb(S807/S811) | 45.71 | p-S6(S235/S236 | 39.27 | 2 | WM115-signal2 | G3 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 208.71 | p-Rb(S807/S811) | 69.04 | p-S6(S235/S236 | 185.81 | 2 | WM115-signal2 | G10 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 189.27 | p-Rb(S807/S811) | 66.71 | p-S6(S235/S236 | 192.92 | 2 | WM115-signal2 | G11 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 179.49 | p-Rb(S807/S811) | 67.38 | p-S6(S235/S236 | 142.55 | 2 | WM115-signal2 | G7 |
| Vemurafenib | WM-115 | JNK-IN-8 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 259.78 | p-Rb(S807/S811) | 60.44 | p-S6(S235/S236 | 25.02 | 2 | WM115-signal2 | G2 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 182.30 | p-Rb(S807/S811) | 53.72 | p-S6(S235/S236 | 104.93 | 1 | WM115-signal2 | F6 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 199.08 | p-Rb(S807/S811) | 67.78 | p-S6(S235/S236 | 151.66 | 1 | WM115-signal2 | F7 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | p-Rb(S807/S811) | p-S6(S235/S236 | 1 | WM115-signal2 | F8 | |||
| Vemurafenib | WM-115 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 206.61 | p-Rb(S807/S811) | 41.17 | p-S6(S235/S236 | 77.73 | 1 | WM115-signal2 | F5 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 202.11 | p-Rb(S807/S811) | 70.44 | p-S6(S235/S236 | 160.70 | 2 | WM115-signal2 | G8 |
| JNK-IN-8 | WM-115 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 257.79 | p-Rb(S807/S811) | 79.63 | p-S6(S235/S236 | 207.22 | 2 | WM115-signal2 | E3 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | p-Rb(S807/S811) | p-S6(S235/S236 | 1 | WM115-signal2 | F9 | |||
| JNK-IN-8 | WM-115 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 223.09 | p-Rb(S807/S811) | 70.57 | p-S6(S235/S236 | 184.86 | 2 | WM115-signal2 | E8 | |
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 225.21 | p-Rb(S807/S811) | 68.46 | p-S6(S235/S236 | 185.57 | 2 | WM115-signal2 | E9 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 205.62 | p-Rb(S807/S811) | 70.03 | p-S6(S235/S236 | 181.80 | 1 | WM115-signal2 | F10 |
| JNK-IN-8 | WM-115 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 236.12 | p-Rb(S807/S811) | 76.30 | p-S6(S235/S236 | 187.61 | 2 | WM115-signal2 | E7 | |
| JNK-IN-8 | WM-115 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 232.27 | p-Rb(S807/S811) | 78.02 | p-S6(S235/S236 | 185.29 | 2 | WM115-signal2 | E4 | |
| JNK-IN-8 | WM-115 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 260.22 | p-Rb(S807/S811) | 76.23 | p-S6(S235/S236 | 189.51 | 2 | WM115-signal2 | E5 | |
| JNK-IN-8 | WM-115 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 243.03 | p-Rb(S807/S811) | 77.65 | p-S6(S235/S236 | 178.01 | 2 | WM115-signal2 | E6 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 203.04 | p-Rb(S807/S811) | 68.91 | p-S6(S235/S236 | 195.37 | 1 | WM115-signal2 | F11 |
| JNK-IN-8 | WM-115 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 238.07 | p-Rb(S807/S811) | 80.65 | p-S6(S235/S236 | 200.44 | 1 | WM115-signal2 | D3 | |
| JNK-IN-8 | WM-115 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 235.96 | p-Rb(S807/S811) | 79.36 | p-S6(S235/S236 | 186.75 | 1 | WM115-signal2 | D4 | |
| JNK-IN-8 | WM-115 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 205.29 | p-Rb(S807/S811) | 76.65 | p-S6(S235/S236 | 177.08 | 1 | WM115-signal2 | D5 | |
| JNK-IN-8 | WM-115 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 248.53 | p-Rb(S807/S811) | 77.96 | p-S6(S235/S236 | 209.55 | 1 | WM115-signal2 | D2 | |
| JNK-IN-8 | WM-115 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 238.95 | p-Rb(S807/S811) | 79.96 | p-S6(S235/S236 | 176.83 | 1 | WM115-signal2 | D6 |