Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JNK-IN-8 | COLO 858 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 311.93 | p-Rb(S807/S811) | 166.54 | p-S6(S235/S236 | 387.41 | 2 | Colo858-signal2 | E8 | |
| JNK-IN-8 | COLO 858 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 343.78 | p-Rb(S807/S811) | 196.27 | p-S6(S235/S236 | 463.89 | 2 | Colo858-signal2 | E4 | |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 336.86 | p-Rb(S807/S811) | 161.69 | p-S6(S235/S236 | 384.38 | 1 | Colo858-signal2 | F11 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 256.94 | p-Rb(S807/S811) | 69.35 | p-S6(S235/S236 | 26.20 | 1 | Colo858-signal2 | F3 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 168.97 | p-Rb(S807/S811) | 57.67 | p-S6(S235/S236 | 47.25 | 1 | Colo858-signal2 | F4 |
| Vemurafenib | COLO 858 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 326.58 | p-Rb(S807/S811) | 162.30 | p-S6(S235/S236 | 402.84 | 1 | Colo858-signal2 | B10 | |
| Vemurafenib | COLO 858 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 358.86 | p-Rb(S807/S811) | 155.99 | p-S6(S235/S236 | 377.96 | 1 | Colo858-signal2 | B11 | |
| Vemurafenib | COLO 858 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 163.91 | p-Rb(S807/S811) | 54.08 | p-S6(S235/S236 | 23.01 | 1 | Colo858-signal2 | B3 | |
| Vemurafenib | COLO 858 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 165.33 | p-Rb(S807/S811) | 58.60 | p-S6(S235/S236 | 48.12 | 1 | Colo858-signal2 | B4 | |
| Vemurafenib | COLO 858 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 284.31 | p-Rb(S807/S811) | 139.79 | p-S6(S235/S236 | 349.95 | 1 | Colo858-signal2 | B7 | |
| Vemurafenib | COLO 858 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 307.92 | p-Rb(S807/S811) | 162.01 | p-S6(S235/S236 | 403.15 | 1 | Colo858-signal2 | B8 | |
| Vemurafenib | COLO 858 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 254.30 | p-Rb(S807/S811) | 163.98 | p-S6(S235/S236 | 398.31 | 2 | Colo858-signal2 | C10 | |
| Vemurafenib | COLO 858 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 377.25 | p-Rb(S807/S811) | 161.02 | p-S6(S235/S236 | 380.19 | 2 | Colo858-signal2 | C11 | |
| Vemurafenib | COLO 858 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 150.91 | p-Rb(S807/S811) | 54.62 | p-S6(S235/S236 | 93.11 | 2 | Colo858-signal2 | C5 | |
| Vemurafenib | COLO 858 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 174.16 | p-Rb(S807/S811) | 73.24 | p-S6(S235/S236 | 166.46 | 2 | Colo858-signal2 | C6 | |
| Vemurafenib | COLO 858 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 349.40 | p-Rb(S807/S811) | 166.03 | p-S6(S235/S236 | 385.58 | 2 | Colo858-signal2 | C8 | |
| Vemurafenib | COLO 858 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 301.75 | p-Rb(S807/S811) | 164.37 | p-S6(S235/S236 | 394.95 | 2 | Colo858-signal2 | C9 | |
| JNK-IN-8 | COLO 858 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 315.08 | p-Rb(S807/S811) | 253.54 | p-S6(S235/S236 | 620.64 | 1 | Colo858-signal2 | D2 | |
| JNK-IN-8 | COLO 858 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 355.48 | p-Rb(S807/S811) | 234.13 | p-S6(S235/S236 | 567.56 | 1 | Colo858-signal2 | D3 | |
| JNK-IN-8 | COLO 858 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 367.65 | p-Rb(S807/S811) | 192.54 | p-S6(S235/S236 | 440.93 | 1 | Colo858-signal2 | D5 | |
| JNK-IN-8 | COLO 858 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 319.80 | p-Rb(S807/S811) | 180.35 | p-S6(S235/S236 | 422.77 | 1 | Colo858-signal2 | D6 | |
| JNK-IN-8 | COLO 858 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 357.02 | p-Rb(S807/S811) | 174.95 | p-S6(S235/S236 | 420.53 | 2 | Colo858-signal2 | E11 | |
| JNK-IN-8 | COLO 858 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 370.03 | p-Rb(S807/S811) | 260.57 | p-S6(S235/S236 | 614.60 | 2 | Colo858-signal2 | E2 | |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 311.80 | p-Rb(S807/S811) | 160.43 | p-S6(S235/S236 | 378.06 | 1 | Colo858-signal2 | F9 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 337.75 | p-Rb(S807/S811) | 156.22 | p-S6(S235/S236 | 357.37 | 1 | Colo858-signal2 | F8 |