Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
Selumetinib C32 3.1600
uM
 24
hr
 1874 601 0.7360 0.8107 0.3207 0.2716 2
Selumetinib C32 3.1600
uM
 24
hr
 1943 456 0.8597 0.8107 0.2347 0.2716 3
Selumetinib C32 3.1600
uM
 24
hr
 2036 447 0.9187 0.8107 0.2196 0.2716 4
Selumetinib C32 3.1600
uM
 48
hr
 1464 1224 0.1168 0.1270 0.8361 0.8303 1
Selumetinib C32 3.1600
uM
 48
hr
 1550 1314 0.1148 0.1270 0.8477 0.8303 2
Selumetinib C32 3.1600
uM
 48
hr
 1431 1172 0.1260 0.1270 0.8190 0.8303 3
Selumetinib C32 3.1600
uM
 48
hr
 1702 1393 0.1504 0.1270 0.8185 0.8303 4
Selumetinib C32 3.1600
uM
 72
hr
 943 840 0.0450 0.0615 0.8908 0.8621 1
Selumetinib C32 3.1600
uM
 72
hr
 1035 878 0.0685 0.0615 0.8483 0.8621 2
Selumetinib C32 3.1600
uM
 72
hr
 924 822 0.0445 0.0615 0.8896 0.8621 3
Selumetinib C32 3.1600
uM
 72
hr
 1114 913 0.0878 0.0615 0.8196 0.8621 4
Vemurafenib C32 0.0032
uM
 24
hr
 1869 177 0.9783 0.9871 0.0947 0.0798 1
Vemurafenib C32 0.0032
uM
 24
hr
 1720 158 0.9031 0.9871 0.0919 0.0798 2
Vemurafenib C32 0.0032
uM
 24
hr
 1998 118 1.0869 0.9871 0.0591 0.0798 3
Vemurafenib C32 0.0032
uM
 24
hr
 1830 135 0.9800 0.9871 0.0738 0.0798 4
Vemurafenib C32 0.0032
uM
 48
hr
 2444 238 1.0734 1.0711 0.0974 0.1099 1
Vemurafenib C32 0.0032
uM
 48
hr
 2120 294 0.8885 1.0711 0.1387 0.1099 2
Vemurafenib C32 0.0032
uM
 48
hr
 2730 260 1.2018 1.0711 0.0952 0.1099 3
Vemurafenib C32 0.0032
uM
 48
hr
 2583 280 1.1206 1.0711 0.1084 0.1099 4
Vemurafenib C32 0.0032
uM
 72
hr
 2388 172 0.9675 1.0406 0.0720 0.0761 1
Vemurafenib C32 0.0032
uM
 72
hr
 2310 172 0.9335 1.0406 0.0745 0.0761 2
Vemurafenib C32 0.0032
uM
 72
hr
 2987 190 1.2212 1.0406 0.0636 0.0761 3
Vemurafenib C32 0.0032
uM
 72
hr
 2631 248 1.0404 1.0406 0.0943 0.0761 4
Vemurafenib C32 0.0100
uM
 24
hr
 1944 298 0.9517 0.9946 0.1533 0.1387 1
Vemurafenib C32 0.0100
uM
 24
hr
 1920 301 0.9360 0.9946 0.1568 0.1387 2