HMS LINCS Project
Library of Integrated Network-based Cellular Signatures
HMS LINCS Database
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JNK-IN-8 KiNativ -- single dose experiment
- Dataset (ID:20213)
Detail
Small Molecules Studied
Cell Lines Studied
Proteins Studied
Data Columns
Results
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Small molecules
Cells
Proteins
10363:JNK-IN-8
50060:A-375
200633:ABL,ARG
200634:ABL,ARG
200635:ACK
200637:AKT1
200638:AKT2,AKT3
200639:AMPKa1,AMPKa2
200640:AMPKa1,AMPKa2
200641:ARAF
200642:ATM
200643:ATR
200644:AurA
200645:AurA,AurB,AurC
200646:AXL
200647:BRAF
200648:CaMK1a
200649:KCC2D
200650:CaMK2g
200651:CaMK2g
200652:CaMKK2
200653:CASK
200654:CDC2
200655:CDK10
200656:CDK11,CDK8
200657:CDK2
200658:CDK2
200659:CDK4
200660:CDK5
200661:CDK5
200662:CDK6
200663:CDK7
200664:CDK9
200665:CHK1
200666:CHK2
200667:KC1A
200668:CK1d,CK1e
200669:CSK
200671:DMPK
200672:DNAPK
200673:DNAPK
200674:DNAPK
200675:DNAPK
200676:eEF2K
200677:eEF2K
200678:EGFR
200679:EPHA2
200680:MK03
200681:MK03
200682:Erk5
200683:FAK
200684:FER
200685:FER
200686:FER
200687:FYN,SRC,YES
200689:GCK
200690:GCK
200691:GCN2_domain2
200692:GCN2_domain2
200693:GSK3A
200694:GSK3B
200695:IKKA
200696:IKKB
200697:IKKE,TBK1
200698:ILK
200699:ILK
200700:IRAK1
200701:IRAK4
200702:IRE1
200703:ITPK1
200704:JAK1
200705:JAK1_domain2
200706:JAK1_domain2
200707:JNK1,JNK2,JNK3
200709:KHS1
200710:KHS1
200711:LATS1
200712:LKB1
200714:LOK
200715:LOK
200716:LOK
200717:LRRK2
200718:MAP2K1
200719:MAP2K1,MAP2K2
200720:MAP2K1,MAP2K2
200722:MAP2K3
200723:MAP2K4
200724:MAP2K4
200725:MAP2K5
200726:MAP2K6
200727:MAP2K6
200728:MAP2K6
200729:MP2K7
200730:MAP3K1
200731:M3K2
200732:M3K2,MAP3K3
200733:MAP3K3
200734:MAP3K4
200735:MAP3K5,MAP3K6,MAP3K7
200736:MAP3K7,TAK1
200737:MARK1
200738:MARK2
200739:MARK2,MARK3
200740:MARK3
200741:MAST1,MAST2
200742:MAST2,MAST4
200743:MAST3
200744:MASTL
200745:MASTL
200746:MLK3
200747:MLKL
200749:MSK1,MSK2_domain1
200750:MSK1_domain1
200751:MST1
200752:MST1
200753:MST1,MST2
200754:MST1,MST2
200755:MST2
200756:MST3
200757:MST3
200758:MST3,MST4,YSK1
200759:MST4,YSK1
200760:NDR1
200761:NDR1
200762:NDR1
200763:NDR1,NDR2
200764:NDR2
200765:NDR2
200766:NDR2
200767:NEK1
200768:NEK6,NEK7
200769:NEK7
200770:NEK7
200771:NEK8
200772:NEK9
200774:NEK9
200775:NEK9
200776:OSR1
200777:p38d,p38g
200778:KS6B1
200779:KS6B1
200780:p70S6K,p70S6Kb
200781:KS6B2
200782:KS6B2
200783:CDK16
200784:PCTAIRE2
200785:PCTAIRE2,PCTAIRE3
200786:PCTAIRE2,PCTAIRE3
200787:CDK14
200788:PHKg2
200789:PI4KA,PI4KAP2
200790:PI4KB
200791:PI4KB
200792:PIK3C3
200793:PIK3C3
200794:PIK3CA
200795:PIK3CB
200796:PIK3CD
200797:PIP4K2A
200798:PI42C
200799:PI42C
200800:FYV1
200801:PITSLRE
200803:KPCT
200804:PKD1
200805:PKD1,PKD2
200806:PKD2
200807:PKD3
200808:PKN2
200809:PKR
200810:PLK1
200811:PRKACB
200812:PRPK
200813:RAF1
200814:ROCK1,ROCK2
200815:RSK1,RSK2,RSK3_domain1
200816:RSK1,RSK2_domain1
200817:RSK1_domain1
200818:RSK1_domain1
200819:RSK1_domain2
200820:RSK2_domain1
200821:RSK2_domain2
200822:RSK2_domain2
200823:RSK2_domain2
200824:RSK3_domain1
200825:RSKL1_domain1
200826:SGK3
200827:SLK
200828:SLK
200829:SLK
200830:SMG1
200831:SRC
200832:SRC
200833:STLK5
200834:TAO1,TAOK3
200835:TAOK2
200836:TBK1
200837:TLK1
200838:TLK2
200839:ULK3
200840:VRK2
200841:WEE1
200842:Wnk1,Wnk2,Wnk3
200843:Wnk1,Wnk2,Wnk4
200844:WNK4
200845:MLTK
200846:ZC1/HGK
200847:ZC1/HGK,ZC2/TNIK,ZC3/MINK
200848:ZC2/TNIK
200849:ZC2/TNIK,ZC3/MINK
200872:AMPKa1
200875:ATR
200883:KCC2D
200888:CDC2
200894:CHK1
200898:CK2a1
200905:CSK
200907:DGKA
200908:DNAPK
200921:FRAP1
200930:IKKA
200932:IKKB
200933:IKKE
200934:ILK
200937:KSR1,KSR2
200943:M3K2
200951:MET
200956:MST2
200959:MST4,YSK1
200963:NEK6,NEK7
200964:OSR1
200965:p38a
200966:MK14
200969:PAN3
200972:PDK1
200979:PIK4CB
200990:PKR
200996:PRP4
201002:ROCK1
201012:SLK
201235:MELK
201276:TYK2(Kin.Dom.2)
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Small Molecule
Cell Line
Protein
Sequence
Labeling Site
% Inhibition
Assay compound conc
Conc unit
JNK-IN-8
A-375
MAST2,MAST4
DLkPDNLLVTSMGHIK
Lys2
-8.9
1
uM
JNK-IN-8
A-375
MAP2K6
MCDFGISGYLVDSVAkTIDAGCKPYMAPER
Activation Loop
-8.9
1
uM
JNK-IN-8
A-375
p38d,p38g
DLkPGNLAVNEDCELK
Lys2
-8.9
1
uM
JNK-IN-8
A-375
MARK1
DLkAENLLLDGDMNIK
Lys2
8.9
1
uM
JNK-IN-8
A-375
CDK2
DLkPQNLLINTEGAIK
Lys2
-9.0
1
uM
JNK-IN-8
A-375
CDK16
LTDNLVALkEIR
Lys1
-9.0
1
uM
JNK-IN-8
A-375
GCN2_domain2
VQNKLDGCCYAVkR
Lys1
9.0
1
uM
JNK-IN-8
A-375
PIK3CA
RPLWLNWENPDIMSELLFQNNEIIFkNGDDLRQDMLTLQIIR
ATP
-9.2
1
uM
JNK-IN-8
A-375
KCC2D
CMKIPTGQEYAAkIINTK
Lys1
-9.2
1
uM
JNK-IN-8
A-375
NEK8
DLkTQNILLDK
Lys2
-9.6
1
uM
JNK-IN-8
A-375
MARK2
HILTGKEVAVkIIDKTQLNSSSLQK
Lys1
9.6
1
uM
JNK-IN-8
A-375
MAP2K5
DVkPSNMLVNTR
Lys2
-9.7
1
uM
JNK-IN-8
A-375
STLK5
YSVkVLPWLSPEVLQQNLQGYDAK
Activation Loop
9.7
1
uM
JNK-IN-8
A-375
JNK1,JNK2,JNK3
DLkPSNIVVK
Lys2
98.7
1
uM
JNK-IN-8
A-375
ZC2/TNIK
TGQLAAIkVMDVTGDEEEEIKQEINMLKK
Lys1
9.9
1
uM
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