PCI-32765 KiNativ -- single dose experiment - Dataset (ID:20206)
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| Small Molecule | Cell Line | Protein | Sequence | Labeling Site | % Inhibition | Assay compound conc | Conc unit |
|---|---|---|---|---|---|---|---|
| Ibrutinib | Ramos (RA 1) | FRAP1 | IQSIAPSLQVITSKQRPR | ATP | 0.3 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | FYN,SRC,YES | QGAKFPIKWTAPEAALYGR | Activation Loop | 7.8 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | GCK | DIKGANLLLTLQGDVK | Lys2 | -5.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | GSK3A | DIKPQNLLVDPDTAVLK | Lys2 | 0.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | GSK3B | DIKPQNLLLDPDTAVLK | Lys2 | 8.9 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | HPK1 | DKVSGDLVALKMVK | Lys1 | -39.4 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | IKKE | SGELVAVKVFNTTSYLRPR | Lys1 | 9.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | IKKE,TBK1 | DIKPGNIMR | Lys2 | -66.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | ILK | ISMADVKFSFQCPGR | Protein Kinase Domain | -37.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | IRAK4 | DIKSANILLDEAFTAK | Lys2 | 5.7 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | JAK1 | QLASALSYLEDKDLVHGNVCTKNLLLAR | Protein Kinase Domain | -61.4 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | JAK1_domain2 | YDPEGDNTGEQVAVKSLKPESGGNHIADLKK | Lys1 | -24.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | JNK1,JNK2,JNK3 | DLKPSNIVVK | Lys2 | -3.3 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | KHS1 | NVHTGELAAVKIIK | Lys1 | 14.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | LKB1 | DIKPGNLLLTTGGTLK | Lys2 | -6.9 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | LOK | DLKAGNVLMTLEGDIR | Lys2 | -60.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | LYN | VAVKTLKPGTMSVQAFLEEANLMK | Lys1 | -50.0 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | LYN | EGAKFPIKWTAPEAINFGCFTIK | Activation Loop | -23.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | MAP2K1 | IMHRDVKPSNILVNSR | Lys2 | -41.4 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | MAP2K1,MAP2K2 | DVKPSNILVNSR | Lys2 | -8.8 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | MAP2K3 | DVKPSNVLINK | Lys2 | 7.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | MAP2K4 | DIKPSNILLDR | Lys2 | 7.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | MAP2K5 | DVKPSNMLVNTR | Lys2 | 31.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | MAP2K6 | DVKPSNVLINALGQVK | Lys2 | 11.3 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | MP2K7 | DVKPSNILLDER | Lys2 | 9.2 | 1 | uM |