Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | T47D | 100.0 | nM | 6 | hr | 166.72 | 79.29 | p-4EBP1 | 503.53 | |
| GSK1059615 | T47D | 100.0 | nM | 24 | hr | 140.32 | 80.90 | p-4EBP1 | 391.09 | |
| MK2206 | T47D | 100.0 | nM | 6 | hr | 95.40 | 43.13 | p-4EBP1 | 98.74 | |
| MK2206 | T47D | 100.0 | nM | 24 | hr | 136.91 | 80.20 | p-4EBP1 | 327.21 | |
| Triciribine | T47D | 100.0 | nM | 6 | hr | 118.58 | 62.46 | p-4EBP1 | 220.49 | |
| Triciribine | T47D | 100.0 | nM | 24 | hr | 168.90 | 92.35 | p-4EBP1 | 347.75 | |
| Dactolisib | T47D | 100.0 | nM | 6 | hr | 75.87 | 27.61 | p-4EBP1 | 41.17 | |
| Dactolisib | T47D | 100.0 | nM | 24 | hr | 115.67 | 48.83 | p-4EBP1 | 81.26 | |
| Gefitinib | AU565 | 316.0 | nM | 6 | hr | 289.30 | 66.48 | p-4EBP1 | 93.41 | |
| Gefitinib | AU565 | 316.0 | nM | 24 | hr | 434.89 | 100.09 | p-4EBP1 | 142.11 | |
| Torkinib | AU565 | 133.0 | nM | 6 | hr | 361.19 | 57.85 | p-4EBP1 | 13.57 | |
| Torkinib | AU565 | 133.0 | nM | 24 | hr | 372.75 | 66.49 | p-4EBP1 | 29.29 | |
| GSK1059615 | AU565 | 316.0 | nM | 6 | hr | 321.66 | 66.88 | p-4EBP1 | 90.79 | |
| GSK1059615 | AU565 | 316.0 | nM | 24 | hr | 533.38 | 95.38 | p-4EBP1 | 163.35 | |
| MK2206 | AU565 | 316.0 | nM | 6 | hr | 347.95 | 72.52 | p-4EBP1 | 121.39 | |
| MK2206 | AU565 | 316.0 | nM | 24 | hr | 370.64 | 85.47 | p-4EBP1 | 134.62 | |
| Triciribine | AU565 | 316.0 | nM | 6 | hr | 368.02 | 79.69 | p-4EBP1 | 119.34 | |
| Triciribine | AU565 | 316.0 | nM | 24 | hr | 528.59 | 99.67 | p-4EBP1 | 148.63 | |
| Dactolisib | AU565 | 316.0 | nM | 6 | hr | 322.87 | 62.99 | p-4EBP1 | 8.78 | |
| Dactolisib | AU565 | 316.0 | nM | 24 | hr | 439.09 | 68.21 | p-4EBP1 | 13.32 | |
| Gefitinib | HCC1954 | 316.0 | nM | 6 | hr | 165.61 | 45.00 | p-4EBP1 | 62.97 | |
| Gefitinib | HCC1954 | 316.0 | nM | 24 | hr | 250.12 | 113.43 | p-4EBP1 | 137.09 | |
| Torkinib | HCC1954 | 133.0 | nM | 6 | hr | 228.49 | 51.64 | p-4EBP1 | 27.54 | |
| Torkinib | HCC1954 | 133.0 | nM | 24 | hr | 242.04 | 91.23 | p-4EBP1 | 64.69 | |
| GSK1059615 | HCC1954 | 316.0 | nM | 6 | hr | 522.05 | 86.08 | p-4EBP1 | 112.57 | |