Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | AU565 | 0 (control) | 24 | hr | 436.18 | 122.76 | p-4EBP1 | 194.67 | | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 268.49 | 73.16 | p-4EBP1 | 98.25 | | |
| MK2206 | AU565 | 0 (control) | 24 | hr | 403.89 | 132.09 | p-4EBP1 | 209.45 | | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 225.03 | 56.04 | p-4EBP1 | 66.91 | | |
| Triciribine | AU565 | 0 (control) | 24 | hr | 473.12 | 123.96 | p-4EBP1 | 227.44 | | |
| Dactolisib | AU565 | 0 (control) | 6 | hr | 218.03 | 53.42 | p-4EBP1 | 64.33 | | |
| Dactolisib | AU565 | 0 (control) | 24 | hr | 508.92 | 132.23 | p-4EBP1 | 196.24 | | |
| Gefitinib | HCC1954 | 0 (control) | 6 | hr | 317.65 | 68.10 | p-4EBP1 | 77.56 | | |
| Gefitinib | HCC1954 | 0 (control) | 24 | hr | 298.23 | 132.71 | p-4EBP1 | 146.23 | | |
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 211.23 | 44.39 | p-4EBP1 | 52.87 | | |
| Torkinib | HCC1954 | 0 (control) | 24 | hr | 306.93 | 118.80 | p-4EBP1 | 137.40 | | |
| GSK1059615 | HCC1954 | 0 (control) | 6 | hr | 562.01 | 105.00 | p-4EBP1 | 155.98 | | |
| GSK1059615 | HCC1954 | 0 (control) | 24 | hr | 318.75 | 119.61 | p-4EBP1 | 141.96 | | |
| MK2206 | HCC1954 | 0 (control) | 6 | hr | 238.90 | 65.60 | p-4EBP1 | 92.63 | | |
| MK2206 | HCC1954 | 0 (control) | 24 | hr | 323.37 | 131.46 | p-4EBP1 | 171.31 | | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 263.52 | 82.77 | p-4EBP1 | 106.42 | | |
| Triciribine | HCC1954 | 0 (control) | 24 | hr | 320.03 | 109.53 | p-4EBP1 | 131.32 | | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 255.38 | 84.53 | p-4EBP1 | 99.75 | | |
| Dactolisib | HCC1954 | 0 (control) | 24 | hr | 304.21 | 127.11 | p-4EBP1 | 143.88 | | |
| Gefitinib | MCF 10A | 0 (control) | 6 | hr | 453.40 | 162.25 | p-4EBP1 | 316.67 | | |
| Gefitinib | MCF 10A | 0 (control) | 24 | hr | 288.88 | 131.01 | p-4EBP1 | 355.73 | | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 467.47 | 159.41 | p-4EBP1 | 396.36 | | |
| Torkinib | MCF 10A | 0 (control) | 24 | hr | 394.65 | 138.31 | p-4EBP1 | 364.25 | | |
| GSK1059615 | MCF 10A | 0 (control) | 6 | hr | 501.27 | 168.80 | p-4EBP1 | 415.08 | | |
| GSK1059615 | MCF 10A | 0 (control) | 24 | hr | 376.23 | 140.90 | p-4EBP1 | 385.66 | |