Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | T47D | 3.16 | uM | 24 | hr | 184.59 | 60.97 | p-Akt | 17.44 | |
| MK2206 | T47D | 3.16 | uM | 6 | hr | 117.01 | 52.23 | p-Akt | 7.58 | |
| MK2206 | T47D | 3.16 | uM | 24 | hr | 148.48 | 43.55 | p-Akt | 13.45 | |
| Triciribine | T47D | 3.16 | uM | 6 | hr | 117.72 | 59.79 | p-Akt | 12.45 | |
| Triciribine | T47D | 3.16 | uM | 24 | hr | 169.39 | 62.41 | p-Akt | 33.47 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 86.04 | 36.41 | p-Akt | 6.31 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 119.38 | 40.84 | p-Akt | 13.33 | |
| Gefitinib | AU565 | 10.0 | uM | 6 | hr | 191.08 | 38.65 | p-Akt | 14.78 | |
| Gefitinib | AU565 | 10.0 | uM | 24 | hr | 332.91 | 74.69 | p-Akt | 27.00 | |
| Torkinib | AU565 | 10.0 | uM | 6 | hr | 198.03 | 31.21 | p-Akt | 12.37 | |
| Torkinib | AU565 | 10.0 | uM | 24 | hr | 450.70 | 73.04 | p-Akt | 18.94 | |
| GSK1059615 | AU565 | 10.0 | uM | 6 | hr | 207.68 | 42.10 | p-Akt | 13.76 | |
| GSK1059615 | AU565 | 10.0 | uM | 24 | hr | 327.44 | 83.88 | p-Akt | 18.75 | |
| MK2206 | AU565 | 10.0 | uM | 6 | hr | 257.70 | 53.65 | p-Akt | 14.45 | |
| MK2206 | AU565 | 10.0 | uM | 24 | hr | 331.32 | 68.08 | p-Akt | 18.16 | |
| Triciribine | AU565 | 10.0 | uM | 6 | hr | 331.62 | 71.61 | p-Akt | 21.64 | |
| Triciribine | AU565 | 10.0 | uM | 24 | hr | 378.92 | 61.61 | p-Akt | 25.10 | |
| Dactolisib | AU565 | 10.0 | uM | 6 | hr | 278.17 | 60.68 | p-Akt | 17.28 | |
| Dactolisib | AU565 | 10.0 | uM | 24 | hr | 452.82 | 70.98 | p-Akt | 21.40 | |
| Gefitinib | HCC1954 | 10.0 | uM | 6 | hr | 142.98 | 43.33 | p-Akt | 20.79 | |
| Gefitinib | HCC1954 | 10.0 | uM | 24 | hr | 250.79 | 68.52 | p-Akt | 42.55 | |
| Torkinib | HCC1954 | 10.0 | uM | 6 | hr | 209.88 | 40.62 | p-Akt | 12.29 | |
| Torkinib | HCC1954 | 10.0 | uM | 24 | hr | 267.05 | 60.22 | p-Akt | 16.95 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 6 | hr | 362.09 | 70.59 | p-Akt | 16.31 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 24 | hr | 303.42 | 61.84 | p-Akt | 18.55 | |