Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | HCC1954 | 562.0 | nM | 6 | hr | 166.11 | 26.07 | p-Akt | 12.65 | |
| Torkinib | HCC1954 | 562.0 | nM | 24 | hr | 245.48 | 68.76 | p-Akt | 21.08 | |
| GSK1059615 | HCC1954 | 1.0 | uM | 6 | hr | 340.19 | 79.16 | p-Akt | 19.95 | |
| GSK1059615 | HCC1954 | 1.0 | uM | 24 | hr | 289.77 | 58.56 | p-Akt | 18.53 | |
| MK2206 | HCC1954 | 1.0 | uM | 6 | hr | 154.63 | 35.58 | p-Akt | 11.74 | |
| MK2206 | HCC1954 | 1.0 | uM | 24 | hr | 242.00 | 86.91 | p-Akt | 18.32 | |
| Triciribine | HCC1954 | 1.0 | uM | 6 | hr | 218.47 | 78.02 | p-Akt | 28.41 | |
| Triciribine | HCC1954 | 1.0 | uM | 24 | hr | 235.33 | 91.33 | p-Akt | 29.69 | |
| Dactolisib | HCC1954 | 1.0 | uM | 6 | hr | 235.17 | 64.66 | p-Akt | 16.95 | |
| Dactolisib | HCC1954 | 1.0 | uM | 24 | hr | 288.44 | 57.74 | p-Akt | 18.48 | |
| Gefitinib | MCF 10A | 1.0 | uM | 6 | hr | 183.24 | 141.46 | p-Akt | 28.84 | |
| Gefitinib | MCF 10A | 1.0 | uM | 24 | hr | 158.54 | 29.78 | p-Akt | 17.71 | |
| Torkinib | MCF 10A | 562.0 | nM | 6 | hr | 506.42 | 142.72 | p-Akt | 18.39 | |
| Torkinib | MCF 10A | 562.0 | nM | 24 | hr | 387.02 | 90.98 | p-Akt | 13.16 | |
| GSK1059615 | MCF 10A | 1.0 | uM | 6 | hr | 215.88 | 128.98 | p-Akt | 16.35 | |
| GSK1059615 | MCF 10A | 1.0 | uM | 24 | hr | 270.51 | 77.62 | p-Akt | 15.17 | |
| MK2206 | MCF 10A | 1.0 | uM | 6 | hr | 371.64 | 151.24 | p-Akt | 19.17 | |
| MK2206 | MCF 10A | 1.0 | uM | 24 | hr | 305.61 | 145.88 | p-Akt | 15.53 | |
| Triciribine | MCF 10A | 1.0 | uM | 6 | hr | 373.41 | 152.18 | p-Akt | 19.21 | |
| Triciribine | MCF 10A | 1.0 | uM | 24 | hr | 304.69 | 113.47 | p-Akt | 20.17 | |
| Dactolisib | MCF 10A | 1.0 | uM | 6 | hr | 296.79 | 139.90 | p-Akt | 18.30 | |
| Dactolisib | MCF 10A | 1.0 | uM | 24 | hr | 358.73 | 45.31 | p-Akt | 14.31 | |
| Gefitinib | T47D | 1.0 | uM | 6 | hr | 160.75 | 102.16 | p-Akt | 104.17 | |
| Gefitinib | T47D | 1.0 | uM | 24 | hr | 156.94 | 108.01 | p-Akt | 80.72 | |
| Torkinib | T47D | 562.0 | nM | 6 | hr | 149.87 | 76.09 | p-Akt | 15.96 | |