Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| MK2206 | HCC1954 | 10.0 | uM | 6 | hr | 280.35 | 74.41 | p-S6 | 224.87 | |
| MK2206 | HCC1954 | 10.0 | uM | 24 | hr | 304.34 | 68.72 | p-S6 | 96.81 | |
| Triciribine | HCC1954 | 10.0 | uM | 6 | hr | 235.70 | 85.98 | p-S6 | 488.16 | |
| Triciribine | HCC1954 | 10.0 | uM | 24 | hr | 211.66 | 90.86 | p-S6 | 445.45 | |
| Dactolisib | HCC1954 | 10.0 | uM | 6 | hr | 271.28 | 75.36 | p-S6 | 19.47 | |
| Dactolisib | HCC1954 | 10.0 | uM | 24 | hr | 278.87 | 73.43 | p-S6 | 9.91 | |
| Gefitinib | MCF 10A | 10.0 | uM | 6 | hr | 189.15 | 140.64 | p-S6 | 360.84 | |
| Gefitinib | MCF 10A | 10.0 | uM | 24 | hr | 173.33 | 27.59 | p-S6 | 20.83 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 575.82 | 163.71 | p-S6 | 376.86 | |
| Torkinib | MCF 10A | 10.0 | uM | 24 | hr | 497.44 | 82.70 | p-S6 | 209.04 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 6 | hr | 223.02 | 132.43 | p-S6 | 6.72 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 24 | hr | 228.06 | 74.27 | p-S6 | 12.24 | |
| MK2206 | MCF 10A | 10.0 | uM | 6 | hr | 360.85 | 140.88 | p-S6 | 596.25 | |
| MK2206 | MCF 10A | 10.0 | uM | 24 | hr | 422.41 | 85.31 | p-S6 | 406.68 | |
| Triciribine | MCF 10A | 10.0 | uM | 6 | hr | 361.44 | 141.42 | p-S6 | 595.52 | |
| Triciribine | MCF 10A | 10.0 | uM | 24 | hr | 338.32 | 108.32 | p-S6 | 386.89 | |
| Dactolisib | MCF 10A | 10.0 | uM | 6 | hr | 325.09 | 126.50 | p-S6 | 407.13 | |
| Dactolisib | MCF 10A | 10.0 | uM | 24 | hr | 409.16 | 66.25 | p-S6 | 240.60 | |
| Gefitinib | T47D | 10.0 | uM | 6 | hr | 156.59 | 103.96 | p-S6 | 496.01 | |
| Gefitinib | T47D | 10.0 | uM | 24 | hr | 149.27 | 92.02 | p-S6 | 299.83 | |
| Torkinib | T47D | 10.0 | uM | 6 | hr | 161.35 | 70.83 | p-S6 | 6.32 | |
| Torkinib | T47D | 10.0 | uM | 24 | hr | 132.29 | 39.88 | p-S6 | 6.28 | |
| GSK1059615 | T47D | 10.0 | uM | 6 | hr | 172.04 | 64.90 | p-S6 | 9.29 | |
| GSK1059615 | T47D | 10.0 | uM | 24 | hr | 196.09 | 61.84 | p-S6 | 8.20 | |
| MK2206 | T47D | 10.0 | uM | 6 | hr | 132.61 | 47.26 | p-S6 | 58.99 | |