Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | HCC1954 | 562.0 | nM | 6 | hr | 166.69 | 30.98 | p-S6 | 11.69 | |
| Torkinib | HCC1954 | 562.0 | nM | 24 | hr | 241.45 | 68.88 | p-S6 | 9.07 | |
| GSK1059615 | HCC1954 | 1.0 | uM | 6 | hr | 388.05 | 76.52 | p-S6 | 10.47 | |
| GSK1059615 | HCC1954 | 1.0 | uM | 24 | hr | 253.56 | 53.10 | p-S6 | 6.70 | |
| MK2206 | HCC1954 | 1.0 | uM | 6 | hr | 189.90 | 61.16 | p-S6 | 130.62 | |
| MK2206 | HCC1954 | 1.0 | uM | 24 | hr | 274.22 | 101.51 | p-S6 | 333.14 | |
| Triciribine | HCC1954 | 1.0 | uM | 6 | hr | 228.86 | 78.69 | p-S6 | 297.01 | |
| Triciribine | HCC1954 | 1.0 | uM | 24 | hr | 214.70 | 97.27 | p-S6 | 342.76 | |
| Dactolisib | HCC1954 | 1.0 | uM | 6 | hr | 247.74 | 76.18 | p-S6 | 16.23 | |
| Dactolisib | HCC1954 | 1.0 | uM | 24 | hr | 278.78 | 63.73 | p-S6 | 9.88 | |
| Gefitinib | MCF 10A | 1.0 | uM | 6 | hr | 176.89 | 153.39 | p-S6 | 470.25 | |
| Gefitinib | MCF 10A | 1.0 | uM | 24 | hr | 206.59 | 65.19 | p-S6 | 244.81 | |
| Torkinib | MCF 10A | 562.0 | nM | 6 | hr | 615.73 | 171.90 | p-S6 | 618.02 | |
| Torkinib | MCF 10A | 562.0 | nM | 24 | hr | 536.99 | 99.33 | p-S6 | 428.19 | |
| GSK1059615 | MCF 10A | 1.0 | uM | 6 | hr | 271.23 | 152.43 | p-S6 | 58.77 | |
| GSK1059615 | MCF 10A | 1.0 | uM | 24 | hr | 315.95 | 95.91 | p-S6 | 38.32 | |
| MK2206 | MCF 10A | 1.0 | uM | 6 | hr | 345.00 | 153.60 | p-S6 | 531.45 | |
| MK2206 | MCF 10A | 1.0 | uM | 24 | hr | 348.34 | 163.69 | p-S6 | 388.73 | |
| Triciribine | MCF 10A | 1.0 | uM | 6 | hr | 346.69 | 154.48 | p-S6 | 534.22 | |
| Triciribine | MCF 10A | 1.0 | uM | 24 | hr | 285.02 | 146.65 | p-S6 | 406.96 | |
| Dactolisib | MCF 10A | 1.0 | uM | 6 | hr | 315.20 | 127.39 | p-S6 | 396.97 | |
| Dactolisib | MCF 10A | 1.0 | uM | 24 | hr | 414.15 | 50.62 | p-S6 | 244.01 | |
| Gefitinib | T47D | 1.0 | uM | 6 | hr | 166.11 | 108.13 | p-S6 | 491.49 | |
| Gefitinib | T47D | 1.0 | uM | 24 | hr | 136.50 | 99.97 | p-S6 | 352.64 | |
| Torkinib | T47D | 562.0 | nM | 6 | hr | 140.25 | 67.60 | p-S6 | 5.64 | |