HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Triciribine	MCF 10A	31.6	nM	24	hr	284.45	143.93	p-S6	272.89
Dactolisib	MCF 10A	31.6	nM	6	hr	358.60	137.93	p-S6	459.09
Dactolisib	MCF 10A	31.6	nM	24	hr	380.40	149.41	p-S6	361.82
Gefitinib	T47D	31.6	nM	6	hr	169.24	103.77	p-S6	460.35
Gefitinib	T47D	31.6	nM	24	hr	149.77	109.46	p-S6	333.14
Torkinib	T47D	7.5	nM	6	hr	166.58	112.68	p-S6	419.40
Torkinib	T47D	7.5	nM	24	hr	146.08	97.87	p-S6	269.37
GSK1059615	T47D	31.6	nM	6	hr	160.95	94.61	p-S6	469.60
GSK1059615	T47D	31.6	nM	24	hr	141.25	93.47	p-S6	327.24
MK2206	T47D	31.6	nM	6	hr	91.91	38.77	p-S6	39.68
MK2206	T47D	31.6	nM	24	hr	140.64	98.09	p-S6	373.71
Triciribine	T47D	31.6	nM	6	hr	106.22	57.85	p-S6	76.25
Triciribine	T47D	31.6	nM	24	hr	157.98	94.11	p-S6	386.15
Dactolisib	T47D	31.6	nM	6	hr	97.27	52.91	p-S6	5.12
Dactolisib	T47D	31.6	nM	24	hr	159.25	59.11	p-S6	13.01
Gefitinib	AU565	100.0	nM	6	hr	246.22	60.31	p-S6	101.43
Gefitinib	AU565	100.0	nM	24	hr	479.44	110.91	p-S6	493.39
Torkinib	AU565	31.6	nM	6	hr	324.77	58.30	p-S6	18.99
Torkinib	AU565	31.6	nM	24	hr	396.33	67.29	p-S6	33.09
GSK1059615	AU565	100.0	nM	6	hr	270.19	66.25	p-S6	102.89
GSK1059615	AU565	100.0	nM	24	hr	456.57	100.82	p-S6	392.83
MK2206	AU565	100.0	nM	6	hr	332.05	77.65	p-S6	125.85
MK2206	AU565	100.0	nM	24	hr	349.02	95.25	p-S6	294.88
Triciribine	AU565	100.0	nM	6	hr	300.85	74.06	p-S6	185.54
Triciribine	AU565	100.0	nM	24	hr	501.15	109.40	p-S6	392.84

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