Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | T47D | 10.0 | nM | 6 | hr | 175.08 | 93.90 | p-4EBP1 | 455.77 | |
| Gefitinib | T47D | 10.0 | nM | 24 | hr | 155.54 | 117.76 | p-4EBP1 | 413.94 | |
| Torkinib | T47D | 1.78 | nM | 6 | hr | 172.48 | 84.00 | p-4EBP1 | 471.08 | |
| Torkinib | T47D | 1.78 | nM | 24 | hr | 157.29 | 96.93 | p-4EBP1 | 355.73 | |
| GSK1059615 | T47D | 10.0 | nM | 6 | hr | 171.35 | 89.96 | p-4EBP1 | 484.98 | |
| GSK1059615 | T47D | 10.0 | nM | 24 | hr | 145.52 | 103.20 | p-4EBP1 | 390.37 | |
| MK2206 | T47D | 10.0 | nM | 6 | hr | 91.29 | 31.15 | p-4EBP1 | 65.25 | |
| MK2206 | T47D | 10.0 | nM | 24 | hr | 136.84 | 105.94 | p-4EBP1 | 360.37 | |
| Triciribine | T47D | 10.0 | nM | 6 | hr | 99.74 | 56.25 | p-4EBP1 | 160.51 | |
| Triciribine | T47D | 10.0 | nM | 24 | hr | 155.46 | 103.90 | p-4EBP1 | 352.38 | |
| Dactolisib | T47D | 10.0 | nM | 6 | hr | 89.53 | 39.74 | p-4EBP1 | 114.99 | |
| Dactolisib | T47D | 10.0 | nM | 24 | hr | 140.73 | 91.20 | p-4EBP1 | 304.17 | |
| Gefitinib | AU565 | 31.6 | nM | 6 | hr | 275.23 | 61.32 | p-4EBP1 | 73.02 | |
| Gefitinib | AU565 | 31.6 | nM | 24 | hr | 502.46 | 129.27 | p-4EBP1 | 151.80 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 277.07 | 52.38 | p-4EBP1 | 54.13 | |
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 429.01 | 96.59 | p-4EBP1 | 145.95 | |
| GSK1059615 | AU565 | 31.6 | nM | 6 | hr | 261.93 | 64.37 | p-4EBP1 | 79.93 | |
| GSK1059615 | AU565 | 31.6 | nM | 24 | hr | 452.71 | 121.60 | p-4EBP1 | 183.35 | |
| MK2206 | AU565 | 31.6 | nM | 6 | hr | 358.63 | 76.79 | p-4EBP1 | 131.88 | |
| MK2206 | AU565 | 31.6 | nM | 24 | hr | 374.92 | 114.21 | p-4EBP1 | 174.44 | |
| Triciribine | AU565 | 31.6 | nM | 6 | hr | 263.33 | 65.75 | p-4EBP1 | 92.92 | |
| Triciribine | AU565 | 31.6 | nM | 24 | hr | 506.30 | 124.42 | p-4EBP1 | 194.23 | |
| Dactolisib | AU565 | 31.6 | nM | 6 | hr | 276.60 | 57.46 | p-4EBP1 | 36.00 | |
| Dactolisib | AU565 | 31.6 | nM | 24 | hr | 418.78 | 76.81 | p-4EBP1 | 75.80 | |
| Gefitinib | HCC1954 | 31.6 | nM | 6 | hr | 206.44 | 51.32 | p-4EBP1 | 66.53 | |