HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
MK2206	MCF 10A	10.0	nM	24	hr	285.94	139.18	p-Akt	32.60
Triciribine	MCF 10A	10.0	nM	6	hr	387.95	153.45	p-Akt	35.77
Triciribine	MCF 10A	10.0	nM	24	hr	270.11	128.63	p-Akt	31.92
Dactolisib	MCF 10A	10.0	nM	6	hr	370.75	172.24	p-Akt	40.19
Dactolisib	MCF 10A	10.0	nM	24	hr	319.07	141.35	p-Akt	35.91
Gefitinib	T47D	10.0	nM	6	hr	175.46	98.50	p-Akt	106.23
Gefitinib	T47D	10.0	nM	24	hr	156.19	107.13	p-Akt	77.30
Torkinib	T47D	1.78	nM	6	hr	166.87	88.81	p-Akt	62.47
Torkinib	T47D	1.78	nM	24	hr	145.76	81.94	p-Akt	44.02
GSK1059615	T47D	10.0	nM	6	hr	166.63	87.35	p-Akt	83.58
GSK1059615	T47D	10.0	nM	24	hr	154.62	91.91	p-Akt	58.78
MK2206	T47D	10.0	nM	6	hr	100.04	46.74	p-Akt	11.24
MK2206	T47D	10.0	nM	24	hr	151.66	90.45	p-Akt	37.91
Triciribine	T47D	10.0	nM	6	hr	106.75	60.43	p-Akt	20.60
Triciribine	T47D	10.0	nM	24	hr	158.90	92.25	p-Akt	60.44
Dactolisib	T47D	10.0	nM	6	hr	101.93	57.67	p-Akt	14.24
Dactolisib	T47D	10.0	nM	24	hr	132.09	76.49	p-Akt	31.82
Gefitinib	AU565	31.6	nM	6	hr	224.67	51.67	p-Akt	24.54
Gefitinib	AU565	31.6	nM	24	hr	497.62	115.28	p-Akt	129.27
Torkinib	AU565	7.5	nM	6	hr	270.94	52.71	p-Akt	17.37
Torkinib	AU565	7.5	nM	24	hr	463.58	90.29	p-Akt	56.28
GSK1059615	AU565	31.6	nM	6	hr	229.64	50.40	p-Akt	23.56
GSK1059615	AU565	31.6	nM	24	hr	469.82	112.04	p-Akt	89.63
MK2206	AU565	31.6	nM	6	hr	207.92	51.79	p-Akt	14.32
MK2206	AU565	31.6	nM	24	hr	349.81	107.21	p-Akt	39.39

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