Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| MK2206 | MCF 10A | 3.16 | uM | 24 | hr | 368.98 | 156.73 | p-S6 | 386.60 | |
| Triciribine | MCF 10A | 3.16 | uM | 6 | hr | 374.42 | 147.32 | p-S6 | 526.58 | |
| Triciribine | MCF 10A | 3.16 | uM | 24 | hr | 288.84 | 139.93 | p-S6 | 304.63 | |
| Dactolisib | MCF 10A | 3.16 | uM | 6 | hr | 279.53 | 122.55 | p-S6 | 382.71 | |
| Dactolisib | MCF 10A | 3.16 | uM | 24 | hr | 363.93 | 62.60 | p-S6 | 228.97 | |
| Gefitinib | T47D | 3.16 | uM | 6 | hr | 156.36 | 109.58 | p-S6 | 497.74 | |
| Gefitinib | T47D | 3.16 | uM | 24 | hr | 150.34 | 111.86 | p-S6 | 364.91 | |
| Torkinib | T47D | 2.37 | uM | 6 | hr | 153.65 | 71.36 | p-S6 | 6.03 | |
| Torkinib | T47D | 2.37 | uM | 24 | hr | 116.01 | 40.48 | p-S6 | 5.28 | |
| GSK1059615 | T47D | 3.16 | uM | 6 | hr | 178.81 | 63.98 | p-S6 | 6.03 | |
| GSK1059615 | T47D | 3.16 | uM | 24 | hr | 216.74 | 68.63 | p-S6 | 9.16 | |
| MK2206 | T47D | 3.16 | uM | 6 | hr | 123.89 | 53.42 | p-S6 | 52.57 | |
| MK2206 | T47D | 3.16 | uM | 24 | hr | 148.11 | 44.41 | p-S6 | 20.30 | |
| Triciribine | T47D | 3.16 | uM | 6 | hr | 129.54 | 76.65 | p-S6 | 153.50 | |
| Triciribine | T47D | 3.16 | uM | 24 | hr | 166.45 | 79.85 | p-S6 | 460.62 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 100.29 | 48.05 | p-S6 | 4.44 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 125.73 | 47.33 | p-S6 | 5.11 | |
| Gefitinib | AU565 | 10.0 | uM | 6 | hr | 246.69 | 58.06 | p-S6 | 11.73 | |
| Gefitinib | AU565 | 10.0 | uM | 24 | hr | 351.75 | 76.74 | p-S6 | 12.88 | |
| Torkinib | AU565 | 10.0 | uM | 6 | hr | 273.78 | 49.97 | p-S6 | 10.61 | |
| Torkinib | AU565 | 10.0 | uM | 24 | hr | 403.84 | 68.50 | p-S6 | 8.41 | |
| GSK1059615 | AU565 | 10.0 | uM | 6 | hr | 260.50 | 63.30 | p-S6 | 7.96 | |
| GSK1059615 | AU565 | 10.0 | uM | 24 | hr | 312.25 | 74.93 | p-S6 | 9.63 | |
| MK2206 | AU565 | 10.0 | uM | 6 | hr | 232.08 | 52.54 | p-S6 | 24.57 | |
| MK2206 | AU565 | 10.0 | uM | 24 | hr | 329.89 | 68.72 | p-S6 | 56.74 | |