HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Gefitinib	MCF 10A	100.0	nM	24	hr	372.85	195.99	p-S6	350.71
Torkinib	MCF 10A	31.6	nM	6	hr	512.25	160.72	p-S6	563.19
Torkinib	MCF 10A	31.6	nM	24	hr	448.72	174.93	p-S6	482.98
GSK1059615	MCF 10A	100.0	nM	6	hr	322.83	163.83	p-S6	503.12
GSK1059615	MCF 10A	100.0	nM	24	hr	315.22	178.09	p-S6	475.32
MK2206	MCF 10A	100.0	nM	6	hr	397.19	152.74	p-S6	455.28
MK2206	MCF 10A	100.0	nM	24	hr	273.76	156.36	p-S6	238.51
Triciribine	MCF 10A	100.0	nM	6	hr	398.49	153.78	p-S6	457.47
Triciribine	MCF 10A	100.0	nM	24	hr	252.76	159.17	p-S6	232.52
Dactolisib	MCF 10A	100.0	nM	6	hr	379.04	131.01	p-S6	368.12
Dactolisib	MCF 10A	100.0	nM	24	hr	341.01	101.82	p-S6	224.62
Gefitinib	T47D	100.0	nM	6	hr	163.38	108.09	p-S6	488.43
Gefitinib	T47D	100.0	nM	24	hr	156.56	119.48	p-S6	347.10
Torkinib	T47D	31.6	nM	6	hr	175.53	86.63	p-S6	15.46
Torkinib	T47D	31.6	nM	24	hr	132.78	57.59	p-S6	16.74
GSK1059615	T47D	100.0	nM	6	hr	181.08	98.61	p-S6	414.99
GSK1059615	T47D	100.0	nM	24	hr	152.54	102.99	p-S6	253.87
MK2206	T47D	100.0	nM	6	hr	98.53	40.39	p-S6	33.35
MK2206	T47D	100.0	nM	24	hr	140.61	97.23	p-S6	375.78
Triciribine	T47D	100.0	nM	6	hr	118.77	80.43	p-S6	187.76
Triciribine	T47D	100.0	nM	24	hr	172.21	96.81	p-S6	431.18
Dactolisib	T47D	100.0	nM	6	hr	80.72	30.01	p-S6	3.74
Dactolisib	T47D	100.0	nM	24	hr	116.78	40.97	p-S6	5.80
Gefitinib	AU565	316.0	nM	6	hr	249.95	67.43	p-S6	79.51
Gefitinib	AU565	316.0	nM	24	hr	435.55	101.60	p-S6	446.57

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