HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
GSK1059615	AU565	3.16	nM	6	hr	218.51	54.15	p-Akt	24.23
GSK1059615	AU565	3.16	nM	24	hr	458.06	113.08	p-Akt	91.73
MK2206	AU565	3.16	nM	6	hr	255.60	70.38	p-Akt	22.59
MK2206	AU565	3.16	nM	24	hr	384.01	117.27	p-Akt	62.56
Triciribine	AU565	3.16	nM	6	hr	205.62	54.24	p-Akt	19.22
Triciribine	AU565	3.16	nM	24	hr	469.42	121.81	p-Akt	100.82
Dactolisib	AU565	3.16	nM	6	hr	259.31	60.60	p-Akt	24.45
Dactolisib	AU565	3.16	nM	24	hr	451.27	106.53	p-Akt	105.91
Gefitinib	HCC1954	3.16	nM	6	hr	285.82	61.71	p-Akt	30.33
Gefitinib	HCC1954	3.16	nM	24	hr	289.89	119.71	p-Akt	80.84
Torkinib	HCC1954	0.422	nM	6	hr	213.03	46.19	p-Akt	24.57
Torkinib	HCC1954	0.422	nM	24	hr	275.88	108.45	p-Akt	62.94
GSK1059615	HCC1954	3.16	nM	6	hr	251.10	72.21	p-Akt	31.16
GSK1059615	HCC1954	3.16	nM	24	hr	310.37	108.43	p-Akt	68.72
MK2206	HCC1954	3.16	nM	6	hr	293.11	80.61	p-Akt	31.92
MK2206	HCC1954	3.16	nM	24	hr	274.49	113.08	p-Akt	59.52
Triciribine	HCC1954	3.16	nM	6	hr	237.48	78.12	p-Akt	40.18
Triciribine	HCC1954	3.16	nM	24	hr	300.93	100.97	p-Akt	59.45
Dactolisib	HCC1954	3.16	nM	6	hr	218.96	75.61	p-Akt	41.58
Dactolisib	HCC1954	3.16	nM	24	hr	294.20	99.05	p-Akt	76.79
Gefitinib	MCF 10A	3.16	nM	6	hr	471.10	159.36	p-Akt	45.78
Gefitinib	MCF 10A	3.16	nM	24	hr	306.15	127.83	p-Akt	46.77
Torkinib	MCF 10A	0.422	nM	6	hr	423.90	157.64	p-Akt	44.17
Torkinib	MCF 10A	0.422	nM	24	hr	369.53	130.31	p-Akt	47.72
GSK1059615	MCF 10A	3.16	nM	6	hr	402.45	167.07	p-Akt	45.00

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