Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | T47D | 562.0 | nM | 24 | hr | 127.25 | 39.63 | p-S6 | 5.53 | |
| GSK1059615 | T47D | 1.0 | uM | 6 | hr | 149.68 | 62.00 | p-S6 | 6.03 | |
| GSK1059615 | T47D | 1.0 | uM | 24 | hr | 157.47 | 47.62 | p-S6 | 7.37 | |
| MK2206 | T47D | 1.0 | uM | 6 | hr | 108.19 | 40.59 | p-S6 | 29.13 | |
| MK2206 | T47D | 1.0 | uM | 24 | hr | 144.69 | 62.76 | p-S6 | 83.17 | |
| Triciribine | T47D | 1.0 | uM | 6 | hr | 107.64 | 46.32 | p-S6 | 53.44 | |
| Triciribine | T47D | 1.0 | uM | 24 | hr | 160.74 | 72.11 | p-S6 | 440.48 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 93.77 | 37.06 | p-S6 | 3.89 | |
| Dactolisib | T47D | 1.0 | uM | 24 | hr | 114.47 | 37.15 | p-S6 | 6.15 | |
| Gefitinib | AU565 | 3.16 | uM | 6 | hr | 253.13 | 58.08 | p-S6 | 23.07 | |
| Gefitinib | AU565 | 3.16 | uM | 24 | hr | 322.27 | 72.00 | p-S6 | 51.48 | |
| Torkinib | AU565 | 2.37 | uM | 6 | hr | 235.92 | 42.12 | p-S6 | 11.49 | |
| Torkinib | AU565 | 2.37 | uM | 24 | hr | 400.68 | 59.69 | p-S6 | 10.43 | |
| GSK1059615 | AU565 | 3.16 | uM | 6 | hr | 203.42 | 46.27 | p-S6 | 7.86 | |
| GSK1059615 | AU565 | 3.16 | uM | 24 | hr | 368.72 | 72.88 | p-S6 | 9.02 | |
| MK2206 | AU565 | 3.16 | uM | 6 | hr | 335.20 | 72.50 | p-S6 | 103.10 | |
| MK2206 | AU565 | 3.16 | uM | 24 | hr | 335.43 | 69.75 | p-S6 | 96.17 | |
| Triciribine | AU565 | 3.16 | uM | 6 | hr | 232.67 | 47.10 | p-S6 | 39.32 | |
| Triciribine | AU565 | 3.16 | uM | 24 | hr | 483.35 | 81.79 | p-S6 | 184.42 | |
| Dactolisib | AU565 | 3.16 | uM | 6 | hr | 200.17 | 43.58 | p-S6 | 11.33 | |
| Dactolisib | AU565 | 3.16 | uM | 24 | hr | 468.32 | 62.94 | p-S6 | 9.55 | |
| Gefitinib | HCC1954 | 3.16 | uM | 6 | hr | 157.55 | 65.04 | p-S6 | 113.86 | |
| Gefitinib | HCC1954 | 3.16 | uM | 24 | hr | 280.95 | 93.46 | p-S6 | 378.35 | |
| Torkinib | HCC1954 | 2.37 | uM | 6 | hr | 169.96 | 27.00 | p-S6 | 11.34 | |
| Torkinib | HCC1954 | 2.37 | uM | 24 | hr | 248.32 | 63.66 | p-S6 | 14.83 | |