Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Docetaxel | BT-549 | -5.0000 | 0.9751 | -8.5540 | -8.3753 | -8.5191 | 1.7370 | 0.2542 | 0.2542 | 4.8575 |
| Docetaxel | HCC1419 | -5.0000 | 0.7471 | -7.7670 | -5.0000 | -7.8886 | 1.6530 | 0.7057 | 0.7057 | 8.4471 |
| Docetaxel | Hs 578T | -5.0000 | 0.9693 | -8.6405 | -8.5044 | -8.8125 | 1.4793 | 0.1759 | 0.1761 | 4.2545 |
| Docetaxel | HCC1395 | -5.0000 | 0.8432 | -8.1310 | -7.8841 | -8.3044 | 2.0065 | 0.3383 | 0.3383 | 5.8332 |
| Docetaxel | HCC1937 | -5.0000 | 0.9371 | -8.2330 | -5.0000 | -8.2189 | 3.9980 | 0.6654 | 0.6654 | 7.3654 |
| Docetaxel | CAMA-1 | -5.0000 | 0.9704 | -8.2760 | -8.0939 | -8.3245 | 3.9980 | 0.4062 | 0.4062 | 5.9096 |
| Docetaxel | AU565 | -5.0000 | 0.9874 | -8.2250 | -8.1981 | -8.3478 | 2.8860 | 0.1007 | 0.1007 | 4.2729 |
| Docetaxel | HCC1954 | -5.0000 | 0.9115 | -8.6430 | -8.5724 | -8.8092 | 1.2620 | 0.0624 | 0.0624 | 3.8091 |
| Docetaxel | MDA-MB-134-VI | -5.0000 | 0.9854 | -8.1760 | -7.8585 | -8.2672 | 1.6740 | 0.3530 | 0.3530 | 7.8615 |
| Docetaxel | HCC38 | -5.0000 | 0.9818 | -8.6120 | -8.4709 | -8.7384 | 1.9535 | 0.2238 | 0.2238 | 4.5902 |
| Docetaxel | MDA-MB-231 | -5.0000 | 0.9692 | -8.5965 | -8.5229 | -8.5833 | 1.6915 | 0.1925 | 0.1925 | 4.2524 |
| Docetaxel | SK-BR-3 | -5.0000 | 0.9657 | -7.8975 | -7.8099 | -8.0272 | 2.7945 | 0.2183 | 0.2183 | 5.3521 |
| Docetaxel | MCF7 | -5.0000 | 0.9618 | -8.0690 | -6.8236 | -7.9760 | 1.1040 | 0.4827 | 0.4828 | 6.4719 |
| Trametinib | ZR75B | -4.7773 | 0.7284 | -7.6263 | -4.7773 | -4.7773 | 0.5066 | 0.8157 | 0.8221 | 8.3485 |
| Trametinib | 600MPE | -4.7773 | 0.9066 | -7.9113 | -4.7773 | -8.1982 | 1.1970 | 0.6256 | 0.6257 | 6.9738 |
| Trametinib | MCF12A | -4.7773 | 0.9782 | -8.4908 | -8.1545 | -8.6879 | 1.1815 | 0.2996 | 0.2996 | 4.9284 |
| Trametinib | HCC2185 | -4.7773 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.3671 |
| Trametinib | SUM52PE | -4.7773 | 0.8128 | -7.8363 | -4.7773 | -7.5320 | 2.8210 | 0.6513 | 0.6513 | 7.8430 |
| Trametinib | SUM229PE | -4.7773 | 0.8615 | -8.0593 | -6.8511 | -8.2068 | 0.6907 | 0.3234 | 0.3271 | 5.4947 |
| Trametinib | 184A1 | -4.7773 | 0.9456 | -8.4983 | -6.0092 | -8.7160 | 1.0862 | 0.4990 | 0.4991 | 6.0545 |
| Trametinib | HCC3153 | -4.7773 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.7877 |
| Trametinib | SUM149PT | -4.7773 | 0.9262 | -8.1218 | -7.0747 | -7.6825 | 0.7057 | 0.3988 | 0.4072 | 5.8683 |
| Trametinib | SUM1315MO2 | -4.7773 | 0.8461 | -6.6293 | -4.8677 | -6.9874 | 0.7539 | 0.5155 | 0.5867 | 7.5543 |
| Trametinib | SUM159PT | -4.7773 | 0.9586 | -8.4253 | -7.8185 | -7.9844 | 0.8062 | 0.3670 | 0.3670 | 5.5186 |
| Trametinib | MCF 10A | -4.7773 | 0.9761 | -8.2693 | -8.0487 | -8.2293 | 1.6805 | 0.2626 | 0.2626 | 4.9256 |