Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Everolimus | ZR75B | -4.1759 | 0.8889 | -6.1339 | -6.1345 | -6.8548 | 0.3386 | 0.0000 | 0.1784 | 5.5339 |
| Triciribine | BT-483 | -4.4776 | 0.8148 | -6.4496 | -4.4776 | -7.6168 | 0.3389 | 0.4704 | 0.5640 | 7.1257 |
| Triciribine | SUM159PT | -4.4776 | 0.9359 | -5.2680 | -5.2680 | -5.4301 | 0.3391 | 0.0000 | 0.3504 | 6.7580 |
| Everolimus | BT-20 | -4.1759 | 0.7773 | -4.5897 | -4.5897 | -5.6990 | 0.3399 | 0.0000 | 0.4197 | 7.2795 |
| Vinorelbine | UACC-812 | -4.3335 | 0.7889 | -5.7975 | -5.7972 | NaN | 0.3422 | 0.0000 | 0.2399 | 6.0818 |
| Everolimus | HCC38 | -4.1759 | 0.8327 | -5.5579 | -5.5579 | NaN | 0.3424 | 0.0000 | 0.2517 | 6.1306 |
| GSK923295 | LY2 | -4.4776 | 0.8034 | -4.9284 | -4.9283 | NaN | 0.3424 | 0.0000 | 0.4121 | 7.1979 |
| Everolimus | HCC1954 | -4.1759 | 0.7598 | -5.5729 | -5.5725 | NaN | 0.3455 | 0.0000 | 0.2477 | 6.1955 |
| Taxol | BT-483 | -4.4776 | 0.7415 | -5.8896 | -4.4776 | -6.9608 | 0.3466 | 0.5285 | 0.6439 | 7.7105 |
| 17-AAG | HCC1428 | -4.0000 | 0.8383 | -6.1110 | -6.1114 | -7.7390 | 0.3469 | 0.0000 | 0.1562 | 5.4574 |
| Temsirolimus | SUM159PT | -3.8761 | 0.8214 | -6.5161 | -6.5159 | -6.6252 | 0.3483 | 0.0000 | 0.1075 | 4.7580 |
| Ixabepilone | SUM225CWN | -4.4045 | 0.7880 | -6.3655 | -6.3658 | -7.3405 | 0.3496 | 0.0000 | 0.1730 | 5.4720 |
| Temsirolimus | HCC1187 | -3.8761 | 0.8466 | -5.2591 | -5.2589 | NaN | 0.3503 | 0.0000 | 0.2469 | 5.9966 |
| Everolimus | SUM159PT | -4.1759 | 0.7663 | -6.0829 | -6.0828 | -6.1150 | 0.3537 | 0.0000 | 0.1747 | 5.7868 |
| Ixabepilone | MX1 | -4.4045 | 0.8381 | -7.1345 | -6.8647 | -8.5408 | 0.3549 | 0.0989 | 0.1863 | 5.0933 |
| Triciribine | SUM229PE | -4.4776 | 0.9202 | -6.1466 | -4.4776 | -6.1103 | 0.3556 | 0.3717 | 0.5072 | 6.9973 |
| Temsirolimus | HCC1419 | -3.8761 | 0.7668 | -5.1381 | -5.1378 | NaN | 0.3556 | 0.0000 | 0.2625 | 6.3054 |
| Temsirolimus | MDA-MB-134-VI | -3.8761 | 0.8091 | -5.1301 | -5.1297 | NaN | 0.3561 | 0.0000 | 0.2635 | 5.9702 |
| Torkinib | UACC-812 | -4.3010 | 0.9736 | -8.7280 | -7.8546 | -10.2600 | 0.3573 | 0.2563 | 0.2753 | 4.2197 |
| Vinorelbine | HCC1937 | -4.3335 | 0.7866 | -5.7920 | -5.7917 | NaN | 0.3574 | 0.0000 | 0.2341 | 6.3165 |
| 5-DFUR | BT-474 | -2.3010 | 0.8103 | -2.0940 | -2.3010 | -3.3351 | 0.3593 | 0.0000 | 0.5427 | 8.0229 |
| CGC-11047 | T47D | -2.3010 | 0.8540 | -3.6230 | -3.6230 | NaN | 0.3613 | 0.0000 | 0.2504 | 6.0812 |
| Pevonedistat | ZR-75-1 | -4.1759 | 0.8384 | -6.2919 | -4.1759 | -6.1022 | 0.3620 | 0.5399 | 0.6072 | 7.4843 |
| Vinorelbine | MDA-MB-175-VII | -4.3335 | 0.7928 | -5.5005 | -5.5004 | NaN | 0.3627 | 0.0000 | 0.2740 | 5.8416 |
| Topotecan | SUM1315MO2 | -3.9626 | 0.9248 | -6.4536 | -6.4541 | -8.0966 | 0.3629 | 0.0000 | 0.1109 | 4.8848 |