Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Trametinib | MDA-MB-361 | -4.7773 | 0.7856 | -5.8653 | -4.7773 | -4.7773 | 0.4957 | 0.8348 | 0.8718 | 8.8515 |
| Etoposide | MCF 10A | -3.4776 | 0.9356 | -5.3466 | -5.3469 | -5.4148 | 0.4964 | 0.0145 | 0.1056 | 5.7838 |
| GSK461364 | MCF12A | -4.4776 | 0.7888 | -5.5836 | -5.5839 | -5.8310 | 0.4970 | 0.0000 | 0.2199 | 6.8984 |
| GSK1070916 | HCC2185 | -4.4776 | 0.8250 | -4.7029 | -4.7028 | -6.4154 | 0.4977 | 0.0000 | 0.4321 | 7.5269 |
| GSK923295 | HCC1419 | -4.4776 | 0.7713 | -4.3252 | -4.4776 | -5.8224 | 0.4978 | 0.0000 | 0.5992 | 8.0203 |
| CGC-11047 | MCF7 | -2.3010 | 0.9410 | -2.4693 | -2.4693 | -3.2887 | 0.4982 | 0.0000 | 0.2197 | 6.9620 |
| Triciribine | HCC2185 | -4.4776 | 0.9381 | -6.7776 | -4.4776 | -7.6786 | 0.4986 | 0.4876 | 0.5091 | 6.7844 |
| Triciribine | MDA-MB-134-VI | -4.4776 | 0.9055 | -6.5306 | -4.4776 | -6.2585 | 0.4988 | 0.6758 | 0.7038 | 7.8526 |
| Topotecan | 184B5 | -3.9626 | 0.9768 | -6.3746 | -6.3743 | -7.1997 | 0.4995 | 0.0000 | 0.0588 | 4.9385 |
| Tozasertib | BT-20 | -4.0000 | 0.8366 | -4.6124 | -4.6124 | -5.5324 | 0.4999 | 0.0000 | 0.3307 | 7.0328 |
| Triciribine | ZR-75-1 | -4.4776 | 0.7862 | -3.9549 | -4.4776 | -4.9534 | 0.5003 | 0.0001 | 0.6425 | 8.1832 |
| Etoposide | MCF7 | -3.4776 | 0.9319 | -4.6461 | -4.2247 | -5.1533 | 0.5006 | 0.1684 | 0.3706 | 7.1186 |
| Torkinib | BT-549 | -4.3010 | 0.9734 | -7.1280 | -7.1278 | -7.5059 | 0.5019 | 0.0000 | 0.0367 | 4.4051 |
| Etoposide | MDA-MB-453 | -3.4776 | 0.9304 | -4.9746 | -4.6718 | -5.3821 | 0.5025 | 0.1488 | 0.2852 | 6.4842 |
| Torkinib | ZR-75-1 | -4.3010 | 0.9479 | -9.8430 | -8.9499 | -10.7280 | 0.5030 | 0.3223 | 0.3234 | 3.6921 |
| Gefitinib | SUM149PT | -4.4776 | 0.9252 | -5.3205 | -5.3206 | -5.5832 | 0.5041 | 0.0000 | 0.2732 | 7.0793 |
| Trametinib | ZR75B | -4.7773 | 0.7284 | -7.6263 | -4.7773 | -4.7773 | 0.5066 | 0.8157 | 0.8221 | 8.3485 |
| Triciribine | HCC1419 | -4.4776 | 0.8884 | -5.0431 | -4.4776 | -6.6517 | 0.5086 | 0.2758 | 0.5662 | 7.7476 |
| AG1478 | HCC1954 | -3.7773 | 0.9352 | -4.9543 | -4.9541 | -5.5348 | 0.5090 | 0.0000 | 0.2011 | 6.6781 |
| Etoposide | SUM1315MO2 | -3.4776 | 0.9483 | -5.6381 | -5.3511 | -6.5663 | 0.5097 | 0.1409 | 0.2051 | 5.9895 |
| Tozasertib | HCC38 | -4.0000 | 0.9362 | -6.0550 | -6.0552 | -6.5583 | 0.5106 | 0.0000 | 0.0819 | 5.5362 |
| Topotecan | HCC202 | -3.9626 | 0.9567 | -4.9676 | -4.7767 | -6.4536 | 0.5111 | 0.1008 | 0.3116 | 6.9979 |
| Topotecan | Hs 578T | -3.9626 | 0.8659 | -4.1679 | -4.1678 | -4.7001 | 0.5118 | 0.0000 | 0.4398 | 7.7654 |
| Everolimus | 600MPE | -4.1759 | 0.7026 | -3.6713 | -4.1759 | -4.6930 | 0.5121 | 0.0000 | 0.6445 | 8.2411 |
| Lestaurtinib | ZR75B | -4.4776 | 0.9049 | -5.9136 | -5.9140 | -6.3840 | 0.5126 | 0.0000 | 0.1551 | 6.1094 |