Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Oxaliplatin | ZR75B | -3.2013 | 0.9141 | -4.7143 | -4.7144 | -5.5795 | 0.5251 | 0.0000 | 0.1383 | 6.3525 |
| AG1478 | ZR75B | -3.7773 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.7859 |
| Torkinib | ZR75B | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Trametinib | ZR75B | -4.7773 | 0.7284 | -7.6263 | -4.7773 | -4.7773 | 0.5066 | 0.8157 | 0.8221 | 8.3485 |
| Gemcitabine | ZR75B | -3.8416 | 0.7019 | -7.6686 | -3.8416 | -7.4014 | 3.9460 | 0.7177 | 0.7177 | 7.4982 |
| Topotecan | ZR75B | -3.9626 | 0.9273 | -6.1276 | -6.1279 | -7.2077 | 0.3952 | 0.0000 | 0.1239 | 5.3567 |
| CGC-11144 | ZR75B | -3.1500 | 0.9706 | -6.0550 | -6.0199 | -6.4000 | 0.6782 | 0.0265 | 0.0368 | 4.5258 |
| 5-FU | ZR75B | -1.7167 | 0.8295 | -3.7187 | -3.7191 | NaN | 0.2688 | 0.0000 | 0.2246 | 5.2233 |
| Doxorubicin | ZR75B | -6.2596 | 0.8591 | -6.8890 | -6.8889 | -7.3287 | 0.3911 | 0.0000 | 0.3620 | 6.9534 |
| Everolimus | ZR75B | -4.1759 | 0.8889 | -6.1339 | -6.1345 | -6.8548 | 0.3386 | 0.0000 | 0.1784 | 5.5339 |
| GSK461364 | ZR75B | -4.4776 | 0.8442 | -6.5221 | -5.0790 | -7.0316 | 2.1862 | 0.3160 | 0.4216 | 6.9822 |
| Afatinib | ZR75B | -4.1759 | 0.8938 | -5.4319 | -5.4318 | -5.5463 | 2.4010 | 0.0000 | 0.0010 | 6.0160 |
| Ixabepilone | ZR75B | -4.4045 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 5.6203 |
| Vorinostat | ZR75B | -1.7282 | 0.9676 | -3.9042 | -3.8367 | -4.0697 | 1.2250 | 0.0871 | 0.0891 | 5.5659 |
| NU6102 | ZR75B | -4.1759 | 0.8882 | -4.6690 | -4.6279 | -4.8339 | 1.5130 | 0.0667 | 0.2087 | 7.6954 |
| Erlotinib | ZR75B | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.9147 |
| Z-Leu-Leu-Norvalinal | ZR75B | -4.1759 | 0.9136 | -5.4989 | -5.3928 | -5.5782 | 1.1820 | 0.1256 | 0.1488 | 6.5886 |
| Omipalisib | ZR75B | -4.4776 | 0.9866 | -8.1786 | -7.9344 | -8.3356 | 0.8804 | 0.1953 | 0.1957 | 4.3371 |
| Nutlin 3a | ZR75B | -4.1759 | 0.9268 | -5.7519 | -5.3211 | -5.7356 | 1.0260 | 0.3194 | 0.3354 | 6.9106 |
| Lestaurtinib | ZR75B | -4.4776 | 0.9049 | -5.9136 | -5.9140 | -6.3840 | 0.5126 | 0.0000 | 0.1551 | 6.1094 |
| Fascaplysin | ZR75B | -4.4776 | 0.9810 | -6.3476 | -6.3463 | -6.4454 | 2.7840 | 0.0030 | 0.0030 | 5.7017 |
| Trichostatin A | ZR75B | -2.3010 | 0.9827 | -5.1260 | -5.0946 | -5.3275 | 1.1750 | 0.0408 | 0.0413 | 4.5727 |
| Valproic acid | ZR75B | -1.8239 | 0.9475 | -2.5406 | -2.5406 | -2.7337 | 1.4670 | 0.0000 | 0.0816 | 7.1588 |
| Triciribine | ZR75B | -4.4776 | 0.8768 | -5.3379 | -5.3377 | -5.8627 | 0.4714 | 0.0000 | 0.2822 | 6.7431 |
| Geldanamycin | ZR75B | -4.0000 | 0.9165 | -7.3490 | -5.1353 | -7.0680 | 1.3610 | 0.4890 | 0.4901 | 6.6445 |