Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Etoposide | HCC1187 | -3.4776 | 0.9482 | -5.6686 | -5.6686 | -6.2307 | 0.8275 | 0.0000 | 0.0178 | 5.3989 |
| (Z)-4-Hydroxytamoxifen | HCC38 | -3.7773 | 0.9421 | -4.1358 | -4.1358 | -4.2562 | 2.2120 | 0.0000 | 0.1387 | 8.5309 |
| Lestaurtinib | UACC-812 | -4.4776 | 0.9075 | -5.5307 | -5.5307 | -6.1955 | 0.9419 | 0.0000 | 0.0945 | 6.7829 |
| Lestaurtinib | UACC-893 | -4.4776 | 0.9446 | -5.3436 | -5.3437 | -5.7235 | 2.2240 | 0.0000 | 0.0117 | 7.4229 |
| (Z)-4-Hydroxytamoxifen | MDA-MB-134-VI | -3.7773 | 0.7481 | -3.0115 | -3.7773 | NaN | 0.2750 | 0.0000 | 0.6189 | 7.7008 |
| Lestaurtinib | ZR-75-1 | -4.4776 | 0.8071 | -4.9951 | -4.9951 | -5.8634 | 0.5333 | 0.0000 | 0.3460 | 7.1442 |
| Lestaurtinib | 184B5 | -4.4776 | 0.9783 | -6.2066 | -6.2065 | -6.5206 | 0.9772 | 0.0000 | 0.0200 | 5.8920 |
| (Z)-4-Hydroxytamoxifen | MDA-MB-361 | -3.7773 | 0.7548 | -4.1147 | -4.1147 | -4.3271 | 1.4940 | 0.0000 | 0.2385 | 8.4179 |
| (Z)-4-Hydroxytamoxifen | MDA-MB-453 | -3.7773 | 0.9162 | -4.4346 | -4.4346 | -4.5472 | 3.0095 | 0.0000 | 0.0956 | 7.7446 |
| Lestaurtinib | HCC1187 | -4.4776 | 0.8869 | -5.6306 | -5.6305 | -6.0003 | 0.6822 | 0.0000 | 0.1405 | 6.9718 |
| Etoposide | MDA-MB-157 | -3.4776 | 0.9397 | -5.2866 | -5.2864 | -6.0724 | 0.5334 | 0.0000 | 0.0978 | 5.7275 |
| Lestaurtinib | MCF 10A | -4.4776 | 0.9399 | -6.2046 | -6.2048 | -6.3193 | 0.6804 | 0.0000 | 0.0626 | 5.7908 |
| (Z)-4-Hydroxytamoxifen | MCF 10A | -3.7773 | 0.8658 | -4.4239 | -4.4238 | -4.4751 | 3.0320 | 0.0000 | 0.0026 | 7.8861 |
| (Z)-4-Hydroxytamoxifen | SUM1315MO2 | -3.7773 | 0.9741 | -4.2677 | -4.2677 | -4.4471 | 3.9990 | 0.0000 | 0.0108 | 8.3928 |