Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Doxorubicin | ZR75B | -6.2596 | 0.8591 | -6.8890 | -6.8889 | -7.3287 | 0.3911 | 0.0000 | 0.3620 | 6.9534 |
| GSK461364 | ZR75B | -4.4776 | 0.8442 | -6.5221 | -5.0790 | -7.0316 | 2.1862 | 0.3160 | 0.4216 | 6.9822 |
| AG1478 | ZR75B | -3.7773 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.7859 |
| Docetaxel | ZR75B | -5.0000 | 0.9309 | -8.2560 | -5.0000 | -7.9688 | 2.3085 | 0.6759 | 0.6759 | 7.3742 |
| Geldanamycin | ZR75B | -4.0000 | 0.9165 | -7.3490 | -5.1353 | -7.0680 | 1.3610 | 0.4890 | 0.4901 | 6.6445 |
| PD173074 | ZR75B | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Bosutinib | ZR75B | -4.0000 | 0.8570 | -5.2020 | -4.9518 | -5.2095 | 1.6070 | 0.3021 | 0.3102 | 7.0835 |
| GSK1070916 | ZR75B | -4.4776 | 0.8084 | -4.6326 | -4.6513 | -5.7720 | 0.3741 | 0.0000 | 0.4696 | 7.4366 |
| Trametinib | ZR75B | -4.7773 | 0.7284 | -7.6263 | -4.7773 | -4.7773 | 0.5066 | 0.8157 | 0.8221 | 8.3485 |
| Fascaplysin | ZR75B | -4.4776 | 0.9810 | -6.3476 | -6.3463 | -6.4454 | 2.7840 | 0.0030 | 0.0030 | 5.7017 |
| Etoposide | ZR75B | -3.4776 | 0.9583 | -5.6916 | -5.2187 | -6.0929 | 0.3813 | 0.1698 | 0.2738 | 5.8559 |
| 17-AAG | ZR75B | -4.0000 | 0.9073 | -7.1760 | -6.5912 | -7.3418 | 0.8582 | 0.3382 | 0.3399 | 5.7616 |
| GSK1059615 | ZR75B | -3.8761 | 0.9793 | -6.3201 | -6.1835 | -6.5403 | 1.3120 | 0.1690 | 0.1695 | 5.7162 |
| Etoposide | ZR-75-1 | -3.4776 | 0.9632 | -5.1636 | -4.6227 | -5.6989 | 0.6001 | 0.2631 | 0.3291 | 6.8258 |
| 17-AAG | ZR-75-1 | -4.0000 | 0.9417 | -6.8275 | -6.6116 | -6.8577 | 3.3130 | 0.3959 | 0.3959 | 6.4398 |
| 5-DFUR | ZR-75-1 | -2.3010 | 0.8335 | -5.2335 | -3.0525 | -5.3717 | 0.3718 | 0.4176 | 0.4622 | 6.2786 |
| Fascaplysin | ZR-75-1 | -4.4776 | 0.9876 | -6.3036 | -6.3012 | -6.4821 | 2.4065 | 0.0064 | 0.0064 | 5.9147 |
| Omipalisib | ZR-75-1 | -4.4776 | 0.9752 | -7.6386 | -7.4713 | -8.0848 | 0.9233 | 0.1479 | 0.1496 | 4.7729 |
| Doxorubicin | ZR-75-1 | -6.2596 | 0.9686 | -6.0603 | -6.2596 | -7.1129 | 0.7632 | 0.0000 | 0.5866 | 8.3016 |
| Sigma A6730 | ZR-75-1 | -4.1759 | 0.8786 | -5.2271 | -5.1490 | -6.1834 | 0.5509 | 0.0549 | 0.2948 | 6.7180 |
| Docetaxel | ZR-75-1 | -5.0000 | 0.8419 | -8.3220 | -5.0000 | -7.7256 | 1.4995 | 0.7820 | 0.7820 | 7.9003 |
| Bosutinib | ZR-75-1 | -4.0000 | 0.9250 | -4.7659 | -4.7424 | -4.9383 | 3.0220 | 0.0874 | 0.0954 | 7.5654 |
| Everolimus | ZR-75-1 | -4.1759 | 0.9051 | -7.5059 | -4.1769 | -7.5788 | 0.5665 | 0.4935 | 0.5000 | 6.3481 |
| Trametinib | ZR-75-1 | -4.7773 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.8565 |
| Epirubicin | ZR-75-1 | -3.7645 | 0.9069 | -6.4145 | -6.2822 | -6.6394 | 2.3481 | 0.1882 | 0.1961 | 5.5258 |