LY294002 - Small Molecule (ID:10510-101)

HMS LINCS ID: 10510-101
Name: LY294002
Alternative Names: LY-294002
LINCS ID:
PubChem CID: 3973
ChEBI ID:
ChEMBL ID:
Molecular Mass: 307.12
InChi: InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChi Key: CZQHHVNHHHRRDU-UHFFFAOYSA-N
SMILES: C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-05-06

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
2
(equivalent to 100 nM ≤ Kd < 1µM)
BRD2, BRD3, BRD4, CSNK2A1, CSNK2A2, GSK3A, GSK3B, MTOR, Pik3ca, PIK3CA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIM1, PRKDC
3
(equivalent to 1µM ≤ Kd < 10 µM)
CDK8, Mtor, PDE5A, PIK3C2B, PIK3R1, PIM3, PLK1
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20268
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates.
Analysis
20269
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10510-101-1 LC Laboratories