Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC70	Omipalisib	1	72	sigmoid	sigmoid	HCC70 omipalisib 0 1 72	8	1.358	0.00496	-0.785	1.14	0.0157	-0.775	0.812	0.989	1.34e-06	NA	0.0123	0.0486	0.349	0.011	0.0462	0.833	0.984	3.73e-06	NA
BT-20	Omipalisib	2	72	sigmoid	sigmoid	BT20 omipalisib 0 2 72	8	1.717	0.00324	-0.799	1.1	0.00361	-0.354	4.99	0.808	0.00704	NA	0.00518	0.0194	0.291	0.00429	0.111	1.34	0.968	3.16e-05	NA
HCC70	Omipalisib	2	72	sigmoid	sigmoid	HCC70 omipalisib 0 2 72	8	1.682	0.00746	-0.705	1.01	0.0241	-0.703	0.749	0.991	6.69e-07	NA	0.0135	0.0399	0.359	0.0121	0.0458	0.852	0.989	1.45e-06	NA
BT-20	Torin2	2	72	sigmoid	sigmoid	BT20 Torin2 0 2 72	8	1.733	0.00315	-0.761	0.992	0.0484	-0.95	0.389	0.949	0.000131	NA	0.00804	0.0252	0.336	0.00642	0.0613	0.583	0.974	1.77e-05	NA
BT-20	Omipalisib	1	72	sigmoid	sigmoid	BT20 omipalisib 0 1 72	8	2.078	0.00617	-0.729	0.985	0.0283	-0.739	0.596	0.97	2.83e-05	NA	0.00781	0.0157	0.306	0.00685	0.0597	0.96	0.988	1.57e-06	NA
BT-20	Dactolisib	2	72	sigmoid	sigmoid	BT20 dactolisib 0 2 72	8	1.727	0.00497	-0.212	0.896	0.00652	-0.186	1.17	0.995	1.45e-07	NA	0.00801	0.2	0.382	0.00505	0.211	1.19	0.994	2.07e-07	NA
BT-20	Omipalisib	3	72	sigmoid	sigmoid	BT20 omipalisib 0 3 72	8	2.586	0.00689	-0.587	0.893	0.044	-0.714	0.478	0.958	7.32e-05	NA	0.00572	0.017	0.281	0.00491	0.0669	0.945	0.983	4.7e-06	NA
HCC38	Torin2	3	72	sigmoid	sigmoid	HCC38 Torin2 0 3 72	8	1.385	0.013	-0.624	0.855	0.0547	-0.706	0.615	0.996	8.13e-08	NA	0.0407	0.0986	0.484	0.0311	0.0829	0.669	0.997	3.31e-08	NA
Hs 578T	Omipalisib	1		sigmoid	sigmoid	Hs578T omipalisib 1	8	2.079	0.00552	-0.546	0.842	0.17	-1.0	0.321	0.98	8.1e-06	NA	0.0079	0.0459	0.351	0.0079	0.0	0.369	0.984	4.12e-06	NA
BT-20	Torin1	2	72	sigmoid	sigmoid	BT20 Torin1 0 2 72	8	1.793	0.00766	-0.152	0.806	0.00992	-0.146	0.986	0.986	2.59e-06	NA	0.0131	0.215	0.421	0.00727	0.212	0.936	0.988	1.92e-06	NA
BT-20	Torin2	1	72	sigmoid	sigmoid	BT20 Torin2 0 1 72	8	2.018	0.0185	-0.739	0.803	0.158	-1.0	0.511	0.986	2.9e-06	NA	0.0245	0.0164	0.415	0.0245	0.0	0.616	0.99	1.06e-06	NA
HCC38	Omipalisib	3	72	sigmoid	sigmoid	HCC38 omipalisib 0 3 72	8	1.446	0.0145	-0.503	0.802	0.0539	-0.597	0.6	0.993	3.08e-07	NA	0.0449	0.134	0.499	0.0308	0.107	0.644	0.993	2.98e-07	NA
BT-549	Torin2	3	72	sigmoid	sigmoid	BT549 Torin2 0 3 72	8	1.613	0.00797	-0.254	0.794	0.0216	-0.338	0.517	0.98	8.52e-06	NA	0.0236	0.204	0.458	0.0104	0.191	0.585	0.976	1.3e-05	NA
HCC38	Torin2	2	72	sigmoid	sigmoid	HCC38 Torin2 0 2 72	8	2.140	0.0146	-0.48	0.793	0.0654	-0.634	0.545	0.993	3.78e-07	NA	0.0176	0.056	0.391	0.015	0.0502	0.68	0.989	1.33e-06	NA
HCC38	Dactolisib	3	72	sigmoid	sigmoid	HCC38 dactolisib 0 3 72	8	1.468	0.0082	-0.197	0.778	0.0127	-0.181	0.711	0.993	3.98e-07	NA	0.0268	0.262	0.497	0.00923	0.277	0.757	0.994	2.62e-07	NA
Hs 578T	Torin2	2		sigmoid	sigmoid	Hs578T Torin2 2	8	2.528	0.0153	-0.467	0.778	0.112	-0.771	0.47	0.986	2.55e-06	NA	0.0122	0.0353	0.352	0.0109	0.036	0.668	0.984	4.09e-06	NA
HCC70	Torin2	1	72	sigmoid	sigmoid	HCC70 Torin2 0 1 72	8	1.364	0.0288	-0.732	0.772	0.183	-1.0	0.594	0.991	6.58e-07	NA	0.088	0.0644	0.539	0.088	0.0	0.622	0.988	1.95e-06	NA
HCC70	Omipalisib	3	72	sigmoid	sigmoid	HCC70 omipalisib 0 3 72	8	2.458	0.0158	-0.404	0.771	0.0319	-0.379	0.8	0.99	8.95e-07	NA	0.0148	0.051	0.376	0.0127	0.0733	1.02	0.996	4.59e-08	NA
BT-549	Torin2	2	72	sigmoid	sigmoid	BT549 Torin2 0 2 72	8	1.824	0.00997	-0.281	0.767	0.0212	-0.282	0.594	0.975	1.47e-05	NA	0.0177	0.155	0.438	0.00929	0.188	0.734	0.973	2.02e-05	NA
Hs 578T	Omipalisib	2		sigmoid	sigmoid	Hs578T omipalisib 2	8	2.507	0.0155	-0.52	0.766	0.239	-1.0	0.402	0.993	3.45e-07	NA	0.0114	0.028	0.355	0.0114	0.0	0.468	0.981	6.9e-06	NA
Hs 578T	Trametinib	1		sigmoid	sigmoid	Hs578T trametinib 1	8	2.044	0.00353	-0.00904	0.765	0.00516	-0.0906	0.437	0.992	4.85e-07	NA	0.00661	0.238	0.385	0.00213	0.201	0.456	0.993	3e-07	NA
Hs 578T	Torin2	1		sigmoid	sigmoid	Hs578T Torin2 1	8	2.031	0.015	-0.405	0.761	0.0631	-0.56	0.522	0.992	5.31e-07	NA	0.021	0.0851	0.419	0.0163	0.0756	0.64	0.993	3.63e-07	NA
BT-549	Torin2	1	72	sigmoid	sigmoid	BT549 Torin2 0 1 72	8	1.771	0.0095	-0.218	0.756	0.0155	-0.193	0.672	0.985	3.06e-06	NA	0.0183	0.19	0.452	0.00874	0.218	0.775	0.988	1.88e-06	NA
HCC38	Torin2	1	72	sigmoid	sigmoid	HCC38 Torin2 0 1 72	8	1.778	0.0133	-0.318	0.753	0.0337	-0.369	0.594	0.994	1.98e-07	NA	0.0264	0.148	0.459	0.0158	0.145	0.664	0.994	1.7e-07	NA
BT-549	Omipalisib	3	72	sigmoid	sigmoid	BT549 omipalisib 0 3 72	8	1.777	0.0114	-0.23	0.753	0.0162	-0.178	0.879	0.988	1.64e-06	NA	0.0201	0.183	0.459	0.0112	0.208	0.924	0.991	6.53e-07	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)