Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T Buparlisib 3
sigmoid
sigmoid
Hs578T buparlisib 3
 8 2.890
0.778
-0.425
0.233
1.71
-1.0
1.4
0.998
1.34e-08
NA
0.622
0.0272
0.779
0.622
0.0
1.57
0.991
8.01e-07
NA
Hs 578T CAL-101 2
sigmoid
sigmoid
Hs578T idelalisib 2
 8 2.534
57.5
0.801
0.0636
320.0
-0.507
0.408
0.979
9.58e-06
NA
Inf
0.766
0.923
4.27
0.505
0.495
0.975
1.65e-05
NA
Hs 578T AZD8055 1
sigmoid
sigmoid
Hs578T AZD8055 1
 8 2.009
0.0391
0.073
0.531
0.0347
0.0546
0.975
0.995
1.39e-07
NA
0.0591
0.286
0.565
0.0259
0.27
0.941
0.994
1.73e-07
NA
Hs 578T Buparlisib 2
sigmoid
sigmoid
Hs578T buparlisib 2
 8 2.513
0.665
-0.42
0.251
1.61
-1.0
1.24
0.998
1.14e-08
NA
0.595
0.0445
0.779
0.595
0.0
1.36
0.994
2.48e-07
NA
Hs 578T Alpelisib 1
sigmoid
sigmoid
Hs578T alpelisib 1
 8 2.097
2.3
0.449
0.205
42.0
-1.0
0.378
0.954
9.56e-05
NA
3.9
0.508
0.803
3.9
0.0
0.401
0.94
0.000216
NA
Hs 578T CAL-101 1
sigmoid
sigmoid
Hs578T idelalisib 1
 8 2.050
27.9
0.72
0.0764
4.56
0.356
0.688
0.945
0.000168
NA
18.7
0.734
0.925
18.7
0.0
0.568
0.941
0.000203
NA
Hs 578T AS605240 3
sigmoid
sigmoid
Hs578T AS-605240 3
 8 2.856
63.8
0.588
0.0965
0.826
0.494
1.03
0.983
4.89e-06
NA
5.75
0.518
0.879
0.552
0.465
1.14
0.981
6.87e-06
NA
Hs 578T AZD-6482 3
sigmoid
sigmoid
Hs578T AZD6482 3
 8 2.832
6.09
0.667
0.0547
24.1
-1.0
0.799
0.989
1.5e-06
NA
5.12
0.597
0.93
5.12
0.0
0.861
0.985
3.33e-06
NA
Hs 578T Dactolisib 1
sigmoid
sigmoid
Hs578T dactolisib 1
 8 2.047
0.00952
-0.0606
0.691
0.00928
0.0117
0.91
0.977
1.27e-05
NA
0.0124
0.213
0.443
0.00621
0.259
1.06
0.985
3.61e-06
NA
Hs 578T Buparlisib 1
sigmoid
sigmoid
Hs578T buparlisib 1
 8 2.064
0.55
-0.579
0.308
1.29
-1.0
1.29
0.992
4.22e-07
NA
0.587
0.0401
0.759
0.587
0.0
1.31
0.988
1.94e-06
NA
Hs 578T BX-912 2
sigmoid
sigmoid
Hs578T BX-912 2
 8 2.540
1.07
-0.019
0.174
1.79
-0.489
1.33
0.998
6.37e-09
NA
1.01
0.164
0.828
1.01
0.0
1.4
0.996
7.64e-08
NA
Hs 578T BX-912 3
sigmoid
sigmoid
Hs578T BX-912 3
 8 2.805
1.04
0.0121
0.125
1.09
-0.0661
2.36
0.992
4.22e-07
NA
0.936
0.148
0.883
0.841
0.116
2.45
0.982
5.7e-06
NA
Hs 578T Alpelisib 2
flat
flat
Hs578T alpelisib 2
 8 2.513
Inf
0.668
0.131
0.0
0.668
0.01
0.599
0.0647
0.856
Inf
0.634
0.847
0.0
0.634
0.01
0.541
0.0969
0.833
Hs 578T Alpelisib 3
sigmoid
sigmoid
Hs578T alpelisib 3
 8 2.856
Inf
0.712
0.0759
0.872
0.616
0.828
0.963
5.21e-05
NA
Inf
0.641
0.901
0.65
0.553
0.853
0.955
8.85e-05
NA
Hs 578T AS605240 1
sigmoid
sigmoid
Hs578T AS-605240 1
 8 2.015
0.758
0.341
0.212
0.333
0.265
0.921
0.991
7.83e-07
NA
1.42
0.447
0.811
0.246
0.408
0.964
0.989
1.51e-06
NA
Hs 578T AS605240 2
sigmoid
sigmoid
Hs578T AS-605240 2
 8 2.547
1.89
0.43
0.194
1.81
0.011
0.541
0.988
1.81e-06
NA
1.6
0.426
0.784
0.971
0.117
0.532
0.983
4.67e-06
NA
Hs 578T AZD-6482 1
sigmoid
sigmoid
Hs578T AZD6482 1
 8 2.041
2.04
0.401
0.177
18.5
-1.0
0.498
0.986
2.92e-06
NA
3.16
0.484
0.835
3.16
0.0
0.532
0.98
7.93e-06
NA
Hs 578T AZD-6482 2
sigmoid
sigmoid
Hs578T AZD6482 2
 8 2.508
6.35
0.602
0.121
74.8
-1.0
0.445
0.998
1.12e-08
NA
6.4
0.573
0.86
6.4
0.0
0.475
0.996
6.36e-08
NA
Hs 578T AZD8055 2
sigmoid
sigmoid
Hs578T AZD8055 2
 8 2.480
0.0521
0.149
0.469
0.0387
0.142
1.13
0.999
3.49e-10
NA
0.0495
0.253
0.557
0.0273
0.249
1.16
0.999
4.45e-10
NA
Hs 578T AZD8055 3
sigmoid
sigmoid
Hs578T AZD8055 3
 8 2.886
0.0538
0.232
0.451
0.0311
0.22
1.06
0.995
1.13e-07
NA
0.039
0.247
0.521
0.0208
0.231
0.989
0.995
1.55e-07
NA
Hs 578T Dactolisib 2
sigmoid
sigmoid
Hs578T dactolisib 2
 8 2.509
0.0128
-0.0617
0.655
0.0126
0.00741
0.79
0.974
1.78e-05
NA
0.0105
0.15
0.405
0.00638
0.203
1.04
0.985
3.67e-06
NA
Hs 578T Dactolisib 3
sigmoid
sigmoid
Hs578T dactolisib 3
 8 2.837
0.0118
0.0569
0.624
0.00848
0.115
0.799
0.96
6.53e-05
NA
0.00728
0.164
0.377
0.0043
0.212
1.05
0.968
3.34e-05
NA
Hs 578T BX-912 1
sigmoid
sigmoid
Hs578T BX-912 1
 8 2.001
0.771
-0.202
0.191
1.16
-0.444
1.57
0.997
2.97e-08
NA
0.901
0.159
0.851
0.822
0.0702
1.64
0.994
1.9e-07
NA
Hs 578T Everolimus 1
sigmoid
sigmoid
Hs578T everolimus 1
 8 2.030
1707115.0
0.626
0.318
0.00576
0.429
0.1
0.895
0.00116
NA
2.51e+21
0.657
0.704
0.00121
0.502
0.1
0.893
0.00124
NA
Hs 578T CAL-101 3
sigmoid
sigmoid
Hs578T idelalisib 3
 8 2.874
Inf
0.854
0.0202
1.12
0.835
1.91
0.991
6.68e-07
NA
Inf
0.805
0.972
1.07
0.781
1.92
0.99
9.77e-07
NA
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