LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 21.90 | 11.9 | 0.0013 | 0.0014 | 0.1822 | 0.2336 | 1.5224 | 0.6197 |
| MCF 10A-H2B-mCherry | Dasatinib | 73.49 | 11.9 | Inf | Inf | -0.7187 | -0.7187 | 0.0000 | 0.6199 |
| MCF 10A-H2B-mCherry | Vorinostat | 89.69 | 11.9 | Inf | Inf | 0.5920 | 0.5920 | 0.0000 | 0.6243 |
| MCF 10A-H2B-mCherry | Vorinostat | 80.31 | 11.9 | Inf | Inf | -0.0761 | -0.0761 | 0.0000 | 0.6257 |
| MCF 10A-H2B-mCherry | Trametinib | 85.43 | 11.9 | Inf | Inf | 0.0455 | 0.0455 | 0.0000 | 0.6300 |
| MCF 10A-H2B-mCherry | Trametinib | 30.41 | 11.9 | 0.0023 | 0.0017 | 0.0870 | 0.1475 | 1.2021 | 0.6335 |
| MCF 10A-H2B-mCherry | Vorinostat | 85.43 | 11.9 | Inf | Inf | 0.1827 | 0.1827 | 0.0000 | 0.6413 |
| MCF 10A-H2B-mCherry | Vorinostat | 85.43 | 12.0 | Inf | Inf | 0.1293 | 0.1293 | 0.0000 | 0.6446 |
| MCF 10A-H2B-mCherry | Trametinib | 23.60 | 11.9 | 0.0013 | 0.0015 | 0.2225 | 0.1793 | 1.2585 | 0.6490 |
| MCF 10A-H2B-mCherry | Trametinib | 28.71 | 11.9 | 0.0019 | 0.0014 | 0.0832 | 0.1492 | 1.8509 | 0.6520 |
| MCF 10A-H2B-mCherry | Trametinib | 25.30 | 11.9 | 0.0017 | 0.0014 | 0.1022 | 0.1419 | 1.1785 | 0.6613 |
| MCF 10A-H2B-mCherry | Etoposide | 69.60 | 11.9 | 0.2123 | 0.2955 | -0.4801 | -0.4544 | 3.3746 | 0.6655 |
| MCF 10A-H2B-mCherry | Trametinib | 27.00 | 11.9 | 0.0019 | 0.0016 | 0.0473 | 0.1162 | 1.2836 | 0.6659 |
| MCF 10A-H2B-mCherry | Taxol | 15.08 | 11.9 | 0.0045 | 0.019 | -0.5767 | -0.8583 | 0.7179 | 0.6695 |
| MCF 10A-H2B-mCherry | Palbociclib | 89.69 | 11.9 | Inf | Inf | -0.9796 | -0.9796 | 0.0000 | 0.6834 |
| MCF 10A-H2B-mCherry | Dasatinib | 76.90 | 11.9 | Inf | Inf | -0.8342 | -0.8342 | 0.0000 | 0.7051 |
| MCF 10A-H2B-mCherry | Taxol | 16.79 | 11.9 | 0.0027 | 0.0126 | -0.6222 | -0.8419 | 0.7095 | 0.7366 |
| MCF 10A-H2B-mCherry | Taxol | 69.60 | 11.9 | Inf | Inf | 0.6450 | 0.3071 | 2.4999 | 0.7524 |
| MCF 10A-H2B-mCherry | Etoposide | 71.30 | 11.9 | Inf | Inf | -0.6076 | -0.5220 | 0.7739 | 0.7550 |
| MCF 10A-H2B-mCherry | Taxol | 71.30 | 11.9 | 0.001 | 0.0014 | 0.1323 | -0.2625 | 3.2812 | 0.7769 |
| MCF 10A-H2B-mCherry | Trametinib | 89.69 | 11.9 | Inf | Inf | -0.1007 | -0.1007 | 0.0000 | 0.7813 |
| MCF 10A-H2B-mCherry | Taxol | 18.49 | 11.9 | 0.0018 | 0.0057 | -0.6429 | -0.7171 | 0.7731 | 0.7994 |
| MCF 10A-H2B-mCherry | Dasatinib | 80.31 | 11.9 | Inf | Inf | -0.8783 | -0.8783 | 0.0000 | 0.8067 |
| MCF 10A-H2B-mCherry | Taxol | 54.25 | 11.9 | 0.0012 | 0.0014 | -0.5929 | -0.3570 | 3.0694 | 0.8324 |
| MCF 10A-H2B-mCherry | Taxol | 20.19 | 11.9 | 0.0017 | 0.004 | -0.7188 | -0.6844 | 1.0554 | 0.8484 |