LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Taxol | 55.97 | 11.9 | 0.0014 | 0.0017 | -0.6141 | -0.5226 | 3.9626 | 0.9101 |
| MCF 10A-H2B-mCherry | Taxol | 30.41 | 11.9 | 0.0015 | 0.0022 | -0.7435 | -0.6127 | 2.1579 | 0.8791 |
| MCF 10A-H2B-mCherry | Taxol | 21.90 | 11.9 | 0.0015 | 0.0031 | -0.7607 | -0.6638 | 1.1472 | 0.8704 |
| MCF 10A-H2B-mCherry | Taxol | 66.19 | 11.9 | 0.0015 | 0.0018 | -0.7264 | -0.5641 | 5.0000 | 0.9534 |
| MCF 10A-H2B-mCherry | Taxol | 23.60 | 11.9 | 0.0016 | 0.0029 | -0.7608 | -0.6627 | 1.5068 | 0.8837 |
| MCF 10A-H2B-mCherry | Taxol | 64.49 | 11.9 | 0.0016 | 0.0018 | -0.4233 | -0.4418 | 5.0000 | 0.8544 |
| MCF 10A-H2B-mCherry | Taxol | 28.71 | 11.9 | 0.0016 | 0.0024 | -0.7752 | -0.6453 | 2.1307 | 0.8888 |
| MCF 10A-H2B-mCherry | Taxol | 57.67 | 11.9 | 0.0016 | 0.0019 | -0.7476 | -0.6006 | 5.0000 | 0.9487 |
| MCF 10A-H2B-mCherry | Taxol | 20.19 | 11.9 | 0.0017 | 0.004 | -0.7188 | -0.6844 | 1.0554 | 0.8484 |
| MCF 10A-H2B-mCherry | Taxol | 27.00 | 11.9 | 0.0017 | 0.0026 | -0.8263 | -0.6759 | 2.0774 | 0.8946 |
| MCF 10A-H2B-mCherry | Taxol | 25.30 | 11.9 | 0.0017 | 0.0028 | -0.8322 | -0.6866 | 1.8062 | 0.8951 |
| MCF 10A-H2B-mCherry | Trametinib | 25.30 | 11.9 | 0.0017 | 0.0014 | 0.1022 | 0.1419 | 1.1785 | 0.6613 |
| MCF 10A-H2B-mCherry | Taxol | 18.49 | 11.9 | 0.0018 | 0.0057 | -0.6429 | -0.7171 | 0.7731 | 0.7994 |
| MCF 10A-H2B-mCherry | Trametinib | 27.00 | 11.9 | 0.0019 | 0.0016 | 0.0473 | 0.1162 | 1.2836 | 0.6659 |
| MCF 10A-H2B-mCherry | Trametinib | 28.71 | 11.9 | 0.0019 | 0.0014 | 0.0832 | 0.1492 | 1.8509 | 0.6520 |
| MCF 10A-H2B-mCherry | Trametinib | 30.41 | 11.9 | 0.0023 | 0.0017 | 0.0870 | 0.1475 | 1.2021 | 0.6335 |
| MCF 10A-H2B-mCherry | Taxol | 16.79 | 11.9 | 0.0027 | 0.0126 | -0.6222 | -0.8419 | 0.7095 | 0.7366 |
| MCF 10A-H2B-mCherry | Trametinib | 33.82 | 11.9 | 0.003 | 0.0026 | 0.0616 | 0.1292 | 1.6293 | 0.6149 |
| MCF 10A-H2B-mCherry | Trametinib | 32.11 | 11.9 | 0.0031 | 0.0024 | 0.0500 | 0.1203 | 1.1430 | 0.6178 |
| MCF 10A-H2B-mCherry | Trametinib | 35.52 | 11.9 | 0.0036 | 0.0031 | 0.0908 | 0.0944 | 1.1733 | 0.6178 |
| MCF 10A-H2B-mCherry | Trametinib | 37.23 | 11.9 | 0.0043 | 0.0042 | 0.0602 | 0.0536 | 1.0579 | 0.6101 |
| MCF 10A-H2B-mCherry | Taxol | 15.08 | 11.9 | 0.0045 | 0.019 | -0.5767 | -0.8583 | 0.7179 | 0.6695 |
| MCF 10A-H2B-mCherry | Trametinib | 42.33 | 11.9 | 0.0059 | 0.0053 | 0.0648 | 0.0806 | 1.0732 | 0.5725 |
| MCF 10A-H2B-mCherry | Trametinib | 38.93 | 11.9 | 0.0062 | 0.0061 | 0.0264 | 0.0759 | 1.1491 | 0.5681 |
| MCF 10A-H2B-mCherry | Trametinib | 44.03 | 11.9 | 0.007 | 0.0067 | 0.0180 | 0.0300 | 1.0037 | 0.5719 |