LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Neratinib | 14.50 | 11.8 | 0.1014 | 0.0723 | 0.1817 | 0.1723 | 1.2230 | 0.3790 |
| MCF 10A-H2B-mCherry | Dasatinib | 14.50 | 11.8 | 0.4949 | 9.8532 | 0.0959 | -0.7075 | 0.3145 | 0.4043 |
| MCF 10A-H2B-mCherry | Alpelisib | 14.50 | 11.8 | Inf | Inf | 0.5830 | 0.5830 | 0.0000 | 0.1656 |
| MCF 10A-H2B-mCherry | Etoposide | 14.50 | 11.8 | 1.8736 | 7.8032 | 0.0786 | -0.4739 | 1.6271 | 0.2461 |
| MCF 10A-H2B-mCherry | Vorinostat | 14.50 | 11.8 | 0.9945 | 1.8329 | -0.1577 | -0.3093 | 1.2875 | 0.3330 |
| MCF 10A-H2B-mCherry | Trametinib | 14.50 | 11.8 | Inf | Inf | 0.6020 | 0.6432 | 0.3547 | 0.2812 |
| MCF 10A-H2B-mCherry | Palbociclib | 14.50 | 11.8 | 0.1749 | 0.0968 | 0.2268 | 0.3503 | 2.9383 | 0.3639 |
| MCF 10A-H2B-mCherry | Taxol | 14.50 | 11.8 | 0.0054 | 0.0111 | -0.8917 | -0.8789 | 1.6037 | 0.7582 |
| MCF 10A-H2B-mCherry | Taxol | 16.47 | 11.8 | 0.0034 | 0.0083 | -0.9391 | -0.9437 | 1.3190 | 0.8401 |
| MCF 10A-H2B-mCherry | Vorinostat | 16.47 | 11.8 | 0.7307 | 0.8957 | -0.1818 | -0.1498 | 1.3691 | 0.3637 |
| MCF 10A-H2B-mCherry | Palbociclib | 16.47 | 11.8 | Inf | Inf | 0.1333 | 0.1764 | 0.4900 | 0.4113 |
| MCF 10A-H2B-mCherry | Trametinib | 16.47 | 11.8 | Inf | Inf | 0.4895 | 0.5143 | 0.2747 | 0.3240 |
| MCF 10A-H2B-mCherry | Dasatinib | 16.47 | 11.8 | 0.2976 | 18.1565 | 0.0567 | -0.9754 | 0.3022 | 0.4478 |
| MCF 10A-H2B-mCherry | Neratinib | 16.47 | 11.8 | 0.0475 | 0.0399 | 0.1640 | 0.1862 | 2.9328 | 0.4268 |
| MCF 10A-H2B-mCherry | Etoposide | 16.47 | 11.8 | 1.6068 | 6.9325 | 0.0415 | -0.5219 | 0.9526 | 0.2668 |
| MCF 10A-H2B-mCherry | Alpelisib | 16.47 | 11.8 | Inf | Inf | 0.5437 | 0.5437 | 0.0000 | 0.1861 |
| MCF 10A-H2B-mCherry | Vorinostat | 18.43 | 11.8 | 0.6735 | 0.7755 | -0.1673 | -0.1097 | 1.6052 | 0.3710 |
| MCF 10A-H2B-mCherry | Taxol | 18.43 | 11.8 | 0.003 | 0.0066 | -0.9335 | -0.9228 | 1.4098 | 0.8755 |
| MCF 10A-H2B-mCherry | Etoposide | 18.43 | 11.8 | 1.5522 | 7.8666 | 0.0158 | -0.6134 | 0.7772 | 0.2740 |
| MCF 10A-H2B-mCherry | Alpelisib | 18.43 | 11.8 | Inf | Inf | 0.5222 | 0.6101 | 2.4994 | 0.1797 |
| MCF 10A-H2B-mCherry | Palbociclib | 18.43 | 11.8 | Inf | Inf | 0.0844 | 0.1016 | 0.4161 | 0.4274 |
| MCF 10A-H2B-mCherry | Dasatinib | 18.43 | 11.8 | 0.3036 | 12.6517 | 0.0458 | -0.6348 | 0.3781 | 0.4299 |
| MCF 10A-H2B-mCherry | Neratinib | 18.43 | 11.8 | 0.0448 | 0.0413 | 0.1418 | 0.1300 | 2.9533 | 0.4580 |
| MCF 10A-H2B-mCherry | Trametinib | 18.43 | 11.8 | Inf | 0.0022 | 0.3943 | 0.4937 | 2.5017 | 0.3567 |
| MCF 10A-H2B-mCherry | Taxol | 20.40 | 11.8 | 0.0027 | 0.0057 | -0.9423 | -0.9486 | 1.4238 | 0.9269 |