LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)

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Cell Small Molecule Time Point (hr) Time Interval (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Trametinib 34.19 11.8
0.0057
0.0039
 0.1750 0.1365 1.2451 0.5626
MCF 10A-H2B-mCherry Trametinib 24.34 11.8
0.0023
0.0014
 0.1795 0.2762 1.8365 0.5496
MCF 10A-H2B-mCherry Palbociclib 88.39 11.8
Inf
Inf
 0.1807 0.1415 2.5000 0.1081
MCF 10A-H2B-mCherry Neratinib 14.50 11.8
0.1014
0.0723
 0.1817 0.1723 1.2230 0.3790
MCF 10A-H2B-mCherry Palbociclib 68.68 11.8
Inf
Inf
 0.2001 0.1415 2.5000 0.1170
MCF 10A-H2B-mCherry Trametinib 30.24 11.8
0.0032
0.0024
 0.2038 0.1467 1.4251 0.6040
MCF 10A-H2B-mCherry Vorinostat 82.47 11.8
Inf
Inf
 0.2104 0.1892 2.5000 0.2370
MCF 10A-H2B-mCherry Palbociclib 86.41 11.8
Inf
Inf
 0.2113 -0.0813 2.5000 0.0375
MCF 10A-H2B-mCherry Vorinostat 76.56 11.8
Inf
Inf
 0.2240 0.1921 2.5000 0.2324
MCF 10A-H2B-mCherry Palbociclib 14.50 11.8
0.1749
0.0968
 0.2268 0.3503 2.9383 0.3639
MCF 10A-H2B-mCherry Palbociclib 64.24 12.8
Inf
Inf
 0.2311 0.2111 2.5000 0.0711
MCF 10A-H2B-mCherry Palbociclib 58.33 12.8
Inf
2.7842
 0.2336 0.2251 3.3390 0.1717
MCF 10A-H2B-mCherry Vorinostat 80.50 11.8
Inf
Inf
 0.2547 0.2547 0.0000 0.2783
MCF 10A-H2B-mCherry Palbociclib 56.36 12.8
4.6212
2.9453
 0.2561 0.2318 2.3448 0.1793
MCF 10A-H2B-mCherry Trametinib 22.37 11.8
0.0038
0.0015
 0.2809 0.3571 1.7782 0.4868
MCF 10A-H2B-mCherry Palbociclib 62.27 12.8
Inf
Inf
 0.3703 0.3202 1.2436 0.0891
MCF 10A-H2B-mCherry Trametinib 20.40 11.8
Inf
0.0016
 0.3724 0.4347 1.8504 0.4166
MCF 10A-H2B-mCherry Palbociclib 66.21 12.8
Inf
Inf
 0.3784 0.3627 2.5000 0.0744
MCF 10A-H2B-mCherry Palbociclib 70.65 11.8
Inf
Inf
 0.3868 0.2469 2.5000 0.0899
MCF 10A-H2B-mCherry Trametinib 18.43 11.8
Inf
0.0022
 0.3943 0.4937 2.5017 0.3567
MCF 10A-H2B-mCherry Taxol 51.92 11.8
0.0007
0.0009
 0.3959 -0.1137 3.3858 0.6843
MCF 10A-H2B-mCherry Alpelisib 70.65 11.8
Inf
Inf
 0.4267 0.6197 0.6734 0.2143
MCF 10A-H2B-mCherry Trametinib 16.47 11.8
Inf
Inf
 0.4895 0.5143 0.2747 0.3240
MCF 10A-H2B-mCherry Alpelisib 18.43 11.8
Inf
Inf
 0.5222 0.6101 2.4994 0.1797
MCF 10A-H2B-mCherry Alpelisib 22.37 11.8
Inf
Inf
 0.5252 0.5693 2.5000 0.1619