LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Etoposide | 20.40 | 11.8 | 1.2916 | 6.3768 | -0.0004 | -0.5932 | 0.7629 | 0.2949 |
| MCF 10A-H2B-mCherry | Taxol | 20.40 | 11.8 | 0.0027 | 0.0057 | -0.9423 | -0.9486 | 1.4238 | 0.9269 |
| MCF 10A-H2B-mCherry | Palbociclib | 20.40 | 11.8 | Inf | Inf | 0.0818 | 0.0679 | 0.3009 | 0.4196 |
| MCF 10A-H2B-mCherry | Dasatinib | 20.40 | 11.8 | 0.3216 | 14.6959 | 0.0500 | -0.8825 | 0.3178 | 0.4415 |
| MCF 10A-H2B-mCherry | Alpelisib | 20.40 | 11.8 | Inf | Inf | 0.5314 | 0.5864 | 2.4995 | 0.1792 |
| MCF 10A-H2B-mCherry | Neratinib | 20.40 | 11.8 | 0.0393 | 0.034 | 0.0651 | 0.0625 | 0.9562 | 0.4912 |
| MCF 10A-H2B-mCherry | Vorinostat | 20.40 | 11.8 | 0.6641 | 0.7595 | -0.1413 | -0.1035 | 1.6441 | 0.3747 |
| MCF 10A-H2B-mCherry | Neratinib | 22.37 | 11.8 | 0.0309 | 0.0304 | -0.0400 | 0.0052 | 0.9627 | 0.5264 |
| MCF 10A-H2B-mCherry | Alpelisib | 22.37 | 11.8 | Inf | Inf | 0.5252 | 0.5693 | 2.5000 | 0.1619 |
| MCF 10A-H2B-mCherry | Vorinostat | 22.37 | 11.8 | 0.7098 | 0.8298 | -0.1346 | -0.1146 | 1.6857 | 0.3643 |
| MCF 10A-H2B-mCherry | Etoposide | 22.37 | 11.8 | 1.1454 | 4.6858 | -0.0123 | -0.5864 | 0.7803 | 0.3018 |
| MCF 10A-H2B-mCherry | Dasatinib | 22.37 | 11.8 | 0.4115 | 15.4623 | 0.0244 | -1.0000 | 0.3218 | 0.4271 |
| MCF 10A-H2B-mCherry | Palbociclib | 22.37 | 11.8 | Inf | Inf | 0.0799 | 0.0010 | 0.2557 | 0.3981 |
| MCF 10A-H2B-mCherry | Trametinib | 22.37 | 11.8 | 0.0038 | 0.0015 | 0.2809 | 0.3571 | 1.7782 | 0.4868 |
| MCF 10A-H2B-mCherry | Taxol | 22.37 | 11.8 | 0.0022 | 0.0052 | -0.9405 | -0.9510 | 1.3001 | 0.9473 |
| MCF 10A-H2B-mCherry | Palbociclib | 24.34 | 11.8 | 0.3032 | 1.183 | 0.0538 | -0.0590 | 0.7314 | 0.3869 |
| MCF 10A-H2B-mCherry | Etoposide | 24.34 | 11.8 | 0.8442 | 5.271 | 0.0105 | -0.5578 | 0.8577 | 0.3466 |
| MCF 10A-H2B-mCherry | Alpelisib | 24.34 | 11.8 | Inf | Inf | 0.5356 | -0.1945 | 0.3087 | 0.1509 |
| MCF 10A-H2B-mCherry | Vorinostat | 24.34 | 11.8 | 0.6895 | 0.8517 | -0.1645 | -0.1500 | 1.6640 | 0.3608 |
| MCF 10A-H2B-mCherry | Trametinib | 24.34 | 11.8 | 0.0023 | 0.0014 | 0.1795 | 0.2762 | 1.8365 | 0.5496 |
| MCF 10A-H2B-mCherry | Taxol | 24.34 | 11.8 | 0.002 | 0.0046 | -0.9432 | -0.9101 | 1.2484 | 0.9442 |
| MCF 10A-H2B-mCherry | Dasatinib | 24.34 | 11.8 | 0.5409 | 14.19 | -0.0125 | -1.0000 | 0.3449 | 0.4043 |
| MCF 10A-H2B-mCherry | Neratinib | 24.34 | 11.8 | 0.0284 | 0.0292 | -0.0594 | 0.0081 | 1.1327 | 0.5345 |
| MCF 10A-H2B-mCherry | Trametinib | 26.31 | 11.8 | 0.0024 | 0.0018 | 0.1118 | 0.1831 | 1.6599 | 0.5994 |
| MCF 10A-H2B-mCherry | Taxol | 26.31 | 11.8 | 0.0016 | 0.0039 | -0.9101 | -0.9124 | 1.2276 | 0.9742 |