LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Etoposide | 82.47 | 11.8 | Inf | Inf | -0.6109 | -0.3921 | 2.5000 | 0.5753 |
| MCF 10A-H2B-mCherry | Taxol | 82.47 | 11.8 | 0.0008 | 0.0008 | -0.4992 | -0.3263 | 5.0000 | 0.8223 |
| MCF 10A-H2B-mCherry | Trametinib | 82.47 | 11.8 | Inf | Inf | -0.0247 | 0.0349 | 2.5000 | 0.5380 |
| MCF 10A-H2B-mCherry | Dasatinib | 82.47 | 11.8 | Inf | Inf | -0.9461 | -0.9461 | 0.0000 | 0.4375 |
| MCF 10A-H2B-mCherry | Neratinib | 82.47 | 11.8 | Inf | Inf | -0.2038 | -0.2038 | 0.0000 | 0.4483 |
| MCF 10A-H2B-mCherry | Alpelisib | 84.44 | 11.8 | Inf | Inf | -0.6603 | -0.9436 | 0.4167 | 0.5697 |
| MCF 10A-H2B-mCherry | Taxol | 84.44 | 11.8 | 0.0007 | 0.0008 | -0.5000 | -0.4460 | 5.0000 | 0.9331 |
| MCF 10A-H2B-mCherry | Etoposide | 84.44 | 11.8 | 0.5033 | 0.6125 | -0.4705 | -0.4504 | 4.9982 | 0.5433 |
| MCF 10A-H2B-mCherry | Dasatinib | 84.44 | 11.8 | Inf | Inf | -0.9625 | -0.9625 | 0.0000 | 0.4367 |
| MCF 10A-H2B-mCherry | Vorinostat | 84.44 | 11.8 | Inf | Inf | 0.0363 | -0.0010 | 2.5000 | 0.2746 |
| MCF 10A-H2B-mCherry | Trametinib | 84.44 | 11.8 | Inf | Inf | 0.0511 | 0.0738 | 2.5000 | 0.5285 |
| MCF 10A-H2B-mCherry | Neratinib | 84.44 | 11.8 | Inf | Inf | -0.2686 | -0.2686 | 0.0000 | 0.4519 |
| MCF 10A-H2B-mCherry | Palbociclib | 84.44 | 11.8 | 7.8009 | 9.9225 | -0.0850 | -1.0000 | 5.0000 | 0.0239 |
| MCF 10A-H2B-mCherry | Dasatinib | 86.41 | 11.8 | Inf | Inf | -0.9407 | -0.9407 | 0.0000 | 0.4348 |
| MCF 10A-H2B-mCherry | Trametinib | 86.41 | 11.8 | Inf | Inf | -0.0396 | 0.0266 | 2.5000 | 0.5563 |
| MCF 10A-H2B-mCherry | Vorinostat | 86.41 | 11.8 | Inf | Inf | 0.1733 | 0.1489 | 2.5000 | 0.2719 |
| MCF 10A-H2B-mCherry | Taxol | 86.41 | 11.8 | 0.0006 | 0.0007 | -0.5000 | -0.5432 | 4.9994 | 1.0330 |
| MCF 10A-H2B-mCherry | Etoposide | 86.41 | 11.8 | 0.5335 | 0.637 | -0.3779 | -0.3506 | 4.9992 | 0.4835 |
| MCF 10A-H2B-mCherry | Palbociclib | 86.41 | 11.8 | Inf | Inf | 0.2113 | -0.0813 | 2.5000 | 0.0375 |
| MCF 10A-H2B-mCherry | Alpelisib | 86.41 | 11.8 | Inf | Inf | -0.5643 | -0.9298 | 0.3611 | 0.5327 |
| MCF 10A-H2B-mCherry | Neratinib | 86.41 | 11.8 | Inf | Inf | 0.6220 | 0.6220 | 0.0000 | 0.3526 |
| MCF 10A-H2B-mCherry | Taxol | 88.39 | 11.8 | 0.0006 | 0.0007 | -0.5000 | -0.6119 | 5.0000 | 1.1071 |
| MCF 10A-H2B-mCherry | Trametinib | 88.39 | 11.8 | Inf | Inf | 0.0264 | 0.0453 | 2.5000 | 0.6297 |
| MCF 10A-H2B-mCherry | Dasatinib | 88.39 | 11.8 | Inf | Inf | -0.9411 | -0.9411 | 0.0000 | 0.4784 |
| MCF 10A-H2B-mCherry | Alpelisib | 88.39 | 11.8 | Inf | Inf | -0.5245 | -0.9218 | 0.3023 | 0.5225 |