LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Palbociclib | 76.56 | 11.8 | 7.1386 | 8.822 | -0.1401 | -0.8206 | 5.0000 | 0.0720 |
| MCF 10A-H2B-mCherry | Trametinib | 76.56 | 11.8 | Inf | Inf | -0.0241 | 0.0501 | 2.5000 | 0.4135 |
| MCF 10A-H2B-mCherry | Neratinib | 76.56 | 11.8 | Inf | Inf | -0.6488 | -0.9900 | 0.4587 | 0.4979 |
| MCF 10A-H2B-mCherry | Dasatinib | 76.56 | 11.8 | Inf | Inf | -0.7949 | -0.9180 | 2.5000 | 0.3265 |
| MCF 10A-H2B-mCherry | Etoposide | 76.56 | 11.8 | Inf | Inf | -0.5161 | -0.3658 | 2.5000 | 0.6176 |
| MCF 10A-H2B-mCherry | Taxol | 76.56 | 11.8 | 0.0011 | 0.0012 | -0.1940 | -0.3600 | 4.9956 | 0.8032 |
| MCF 10A-H2B-mCherry | Etoposide | 78.53 | 11.8 | 0.4167 | 0.4886 | -0.6198 | -0.4902 | 4.5677 | 0.6156 |
| MCF 10A-H2B-mCherry | Neratinib | 78.53 | 11.8 | Inf | Inf | -0.7553 | -0.9963 | 1.0525 | 0.4438 |
| MCF 10A-H2B-mCherry | Vorinostat | 78.53 | 11.8 | Inf | Inf | 0.0626 | 0.1037 | 2.4991 | 0.2671 |
| MCF 10A-H2B-mCherry | Palbociclib | 78.53 | 11.8 | 6.8 | 7.9008 | -0.2637 | -0.6220 | 5.0000 | 0.0666 |
| MCF 10A-H2B-mCherry | Trametinib | 78.53 | 11.8 | Inf | Inf | -0.0282 | 0.0198 | 2.5000 | 0.4461 |
| MCF 10A-H2B-mCherry | Dasatinib | 78.53 | 11.8 | Inf | Inf | -0.8878 | -0.9429 | 2.5000 | 0.3438 |
| MCF 10A-H2B-mCherry | Taxol | 78.53 | 11.8 | 0.0011 | 0.0012 | -0.4490 | -0.3760 | 4.9969 | 0.8513 |
| MCF 10A-H2B-mCherry | Alpelisib | 78.53 | 11.8 | Inf | Inf | -0.5687 | -0.7801 | 0.5348 | 0.5215 |
| MCF 10A-H2B-mCherry | Vorinostat | 80.50 | 11.8 | Inf | Inf | 0.2547 | 0.2547 | 0.0000 | 0.2783 |
| MCF 10A-H2B-mCherry | Taxol | 80.50 | 11.8 | 0.0009 | 0.0011 | -0.4560 | -0.4969 | 4.9979 | 0.8957 |
| MCF 10A-H2B-mCherry | Dasatinib | 80.50 | 11.8 | Inf | Inf | -0.9137 | -0.9137 | 0.0000 | 0.3813 |
| MCF 10A-H2B-mCherry | Neratinib | 80.50 | 11.8 | Inf | Inf | -0.3030 | -0.3030 | 0.0000 | 0.4783 |
| MCF 10A-H2B-mCherry | Palbociclib | 80.50 | 11.8 | 6.7725 | 8.2243 | -0.3199 | -0.8211 | 5.0000 | 0.0725 |
| MCF 10A-H2B-mCherry | Trametinib | 80.50 | 11.8 | Inf | Inf | -0.0324 | 0.1443 | 2.5000 | 0.3980 |
| MCF 10A-H2B-mCherry | Etoposide | 80.50 | 11.8 | 0.4604 | 0.5628 | -0.5825 | -0.5212 | 4.2963 | 0.6204 |
| MCF 10A-H2B-mCherry | Alpelisib | 80.50 | 11.8 | Inf | Inf | -0.7248 | -0.9024 | 0.5606 | 0.5652 |
| MCF 10A-H2B-mCherry | Vorinostat | 82.47 | 11.8 | Inf | Inf | 0.2104 | 0.1892 | 2.5000 | 0.2370 |
| MCF 10A-H2B-mCherry | Alpelisib | 82.47 | 11.8 | Inf | Inf | -0.7155 | -0.9323 | 0.4722 | 0.5723 |
| MCF 10A-H2B-mCherry | Palbociclib | 82.47 | 11.8 | 5.9596 | 7.8902 | -0.2712 | -0.8072 | 3.8956 | 0.0791 |