LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 70.65 | 11.8 | 0.0304 | 0.028 | 0.0121 | 0.1724 | 5.0000 | 0.3478 |
| MCF 10A-H2B-mCherry | Vorinostat | 70.65 | 11.8 | 4.0002 | 3.6262 | 0.0895 | 0.1990 | 4.9999 | 0.1728 |
| MCF 10A-H2B-mCherry | Dasatinib | 70.65 | 11.8 | Inf | Inf | -0.4702 | -0.7605 | 2.5000 | 0.2422 |
| MCF 10A-H2B-mCherry | Palbociclib | 70.65 | 11.8 | Inf | Inf | 0.3868 | 0.2469 | 2.5000 | 0.0899 |
| MCF 10A-H2B-mCherry | Alpelisib | 70.65 | 11.8 | Inf | Inf | 0.4267 | 0.6197 | 0.6734 | 0.2143 |
| MCF 10A-H2B-mCherry | Taxol | 70.65 | 11.8 | Inf | Inf | -0.6937 | -0.7735 | 2.5000 | 1.0129 |
| MCF 10A-H2B-mCherry | Neratinib | 70.65 | 11.8 | 0.409 | 0.8755 | -0.7838 | -0.9606 | 2.1901 | 0.4163 |
| MCF 10A-H2B-mCherry | Vorinostat | 72.62 | 11.8 | Inf | Inf | 0.1396 | 0.1396 | 0.0000 | 0.1845 |
| MCF 10A-H2B-mCherry | Dasatinib | 72.62 | 11.8 | Inf | Inf | -0.6968 | -0.8679 | 2.5000 | 0.2828 |
| MCF 10A-H2B-mCherry | Taxol | 72.62 | 11.8 | 0.0011 | 0.0012 | -0.4139 | -0.4353 | 4.9999 | 0.9083 |
| MCF 10A-H2B-mCherry | Palbociclib | 72.62 | 11.8 | Inf | Inf | 0.1477 | 0.0937 | 2.5000 | 0.1111 |
| MCF 10A-H2B-mCherry | Etoposide | 72.62 | 11.8 | Inf | Inf | -0.4368 | -0.3631 | 2.5000 | 0.6217 |
| MCF 10A-H2B-mCherry | Neratinib | 72.62 | 11.8 | Inf | Inf | -0.6829 | -0.9987 | 0.4021 | 0.4642 |
| MCF 10A-H2B-mCherry | Trametinib | 72.62 | 11.8 | 0.0314 | 0.0301 | -0.0207 | 0.1090 | 5.0000 | 0.3790 |
| MCF 10A-H2B-mCherry | Alpelisib | 72.62 | 11.8 | Inf | Inf | 0.1179 | 0.2602 | 0.5184 | 0.2709 |
| MCF 10A-H2B-mCherry | Palbociclib | 74.59 | 11.8 | 6.2258 | 8.3106 | -0.1752 | -0.7583 | 3.9365 | 0.1194 |
| MCF 10A-H2B-mCherry | Taxol | 74.59 | 11.8 | 0.0011 | 0.0012 | -0.1346 | -0.2979 | 4.9959 | 0.7808 |
| MCF 10A-H2B-mCherry | Alpelisib | 74.59 | 11.8 | Inf | Inf | -0.2722 | -0.3540 | 0.4280 | 0.3853 |
| MCF 10A-H2B-mCherry | Neratinib | 74.59 | 11.8 | Inf | Inf | -0.7181 | -0.9989 | 0.6470 | 0.4952 |
| MCF 10A-H2B-mCherry | Vorinostat | 74.59 | 11.8 | Inf | Inf | 0.0392 | 0.0407 | 2.5000 | 0.2224 |
| MCF 10A-H2B-mCherry | Trametinib | 74.59 | 11.8 | Inf | Inf | 0.0817 | 0.0886 | 2.5000 | 0.3756 |
| MCF 10A-H2B-mCherry | Etoposide | 74.59 | 11.8 | Inf | Inf | -0.4921 | -0.3975 | 2.5000 | 0.6448 |
| MCF 10A-H2B-mCherry | Dasatinib | 74.59 | 11.8 | Inf | Inf | -0.7935 | -0.7935 | 0.0000 | 0.3297 |
| MCF 10A-H2B-mCherry | Vorinostat | 76.56 | 11.8 | Inf | Inf | 0.2240 | 0.1921 | 2.5000 | 0.2324 |
| MCF 10A-H2B-mCherry | Alpelisib | 76.56 | 11.8 | Inf | Inf | -0.3605 | -0.5430 | 0.4156 | 0.4223 |