LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 34.19 | 11.8 | 0.0057 | 0.0039 | 0.1750 | 0.1365 | 1.2451 | 0.5626 |
| MCF 10A-H2B-mCherry | Trametinib | 36.16 | 11.8 | 0.0058 | 0.004 | 0.1620 | 0.1287 | 1.1729 | 0.5671 |
| MCF 10A-H2B-mCherry | Trametinib | 38.13 | 11.8 | 0.0074 | 0.0053 | 0.1560 | 0.1209 | 1.2030 | 0.5462 |
| MCF 10A-H2B-mCherry | Trametinib | 40.10 | 11.8 | 0.0085 | 0.008 | 0.0908 | 0.0817 | 1.8608 | 0.5296 |
| MCF 10A-H2B-mCherry | Trametinib | 42.07 | 11.8 | 0.0098 | 0.0098 | 0.0617 | 0.0867 | 3.1683 | 0.5169 |
| MCF 10A-H2B-mCherry | Trametinib | 44.04 | 11.8 | 0.0109 | 0.0109 | 0.0743 | 0.1124 | 3.2317 | 0.4865 |
| MCF 10A-H2B-mCherry | Alpelisib | 56.36 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | 0.0012 |
| MCF 10A-H2B-mCherry | Alpelisib | 58.33 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0079 |
| MCF 10A-H2B-mCherry | Alpelisib | 60.30 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0098 |
| MCF 10A-H2B-mCherry | Alpelisib | 62.27 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0396 |
| MCF 10A-H2B-mCherry | Alpelisib | 64.24 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0006 |
| MCF 10A-H2B-mCherry | Alpelisib | 66.21 | 12.8 | Inf | Inf | 0.7208 | 0.7208 | 0.0000 | 0.0599 |
| MCF 10A-H2B-mCherry | Neratinib | 56.36 | 12.8 | 0.3409 | 0.3863 | -0.2782 | -0.2034 | 3.7838 | 0.2979 |
| MCF 10A-H2B-mCherry | Neratinib | 58.33 | 12.8 | 0.3234 | 0.371 | -0.3872 | -0.2928 | 3.9380 | 0.3253 |
| MCF 10A-H2B-mCherry | Neratinib | 60.30 | 12.8 | 0.3735 | 0.4891 | -0.4937 | -0.4609 | 2.3613 | 0.3388 |
| MCF 10A-H2B-mCherry | Neratinib | 62.27 | 12.8 | 0.3897 | 0.5562 | -0.5658 | -0.5865 | 2.1736 | 0.3542 |
| MCF 10A-H2B-mCherry | Neratinib | 64.24 | 12.8 | 0.4495 | 0.6532 | -0.7536 | -0.7620 | 3.3315 | 0.3860 |
| MCF 10A-H2B-mCherry | Neratinib | 66.21 | 12.8 | 0.4418 | 0.7084 | -0.7114 | -0.8082 | 3.1712 | 0.3995 |
| MCF 10A-H2B-mCherry | Trametinib | 56.36 | 12.8 | 0.0217 | 0.0212 | 0.0706 | 0.0936 | 4.0713 | 0.3913 |
| MCF 10A-H2B-mCherry | Trametinib | 58.33 | 12.8 | 0.0222 | 0.0223 | 0.0302 | 0.0515 | 4.3444 | 0.4024 |
| MCF 10A-H2B-mCherry | Trametinib | 60.30 | 12.8 | 0.0236 | 0.0232 | 0.0787 | 0.0863 | 5.0000 | 0.3806 |
| MCF 10A-H2B-mCherry | Trametinib | 62.27 | 12.8 | 0.0255 | 0.0246 | 0.0151 | 0.0703 | 4.3386 | 0.3770 |
| MCF 10A-H2B-mCherry | Taxol | 56.36 | 12.8 | Inf | Inf | 0.0000 | -0.1380 | 2.5000 | 0.6797 |
| MCF 10A-H2B-mCherry | Taxol | 58.33 | 12.8 | Inf | Inf | -0.3263 | -0.3780 | 2.4987 | 0.6387 |
| MCF 10A-H2B-mCherry | Taxol | 60.30 | 12.8 | Inf | Inf | -0.3554 | -0.6653 | 2.5000 | 0.8293 |