LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Taxol | 16.47 | 11.8 | 0.0034 | 0.0083 | -0.9391 | -0.9437 | 1.3190 | 0.8401 |
| MCF 10A-H2B-mCherry | Alpelisib | 84.44 | 11.8 | Inf | Inf | -0.6603 | -0.9436 | 0.4167 | 0.5697 |
| MCF 10A-H2B-mCherry | Dasatinib | 78.53 | 11.8 | Inf | Inf | -0.8878 | -0.9429 | 2.5000 | 0.3438 |
| MCF 10A-H2B-mCherry | Dasatinib | 88.39 | 11.8 | Inf | Inf | -0.9411 | -0.9411 | 0.0000 | 0.4784 |
| MCF 10A-H2B-mCherry | Dasatinib | 86.41 | 11.8 | Inf | Inf | -0.9407 | -0.9407 | 0.0000 | 0.4348 |
| MCF 10A-H2B-mCherry | Alpelisib | 82.47 | 11.8 | Inf | Inf | -0.7155 | -0.9323 | 0.4722 | 0.5723 |
| MCF 10A-H2B-mCherry | Alpelisib | 86.41 | 11.8 | Inf | Inf | -0.5643 | -0.9298 | 0.3611 | 0.5327 |
| MCF 10A-H2B-mCherry | Taxol | 18.43 | 11.8 | 0.003 | 0.0066 | -0.9335 | -0.9228 | 1.4098 | 0.8755 |
| MCF 10A-H2B-mCherry | Alpelisib | 88.39 | 11.8 | Inf | Inf | -0.5245 | -0.9218 | 0.3023 | 0.5225 |
| MCF 10A-H2B-mCherry | Dasatinib | 76.56 | 11.8 | Inf | Inf | -0.7949 | -0.9180 | 2.5000 | 0.3265 |
| MCF 10A-H2B-mCherry | Dasatinib | 80.50 | 11.8 | Inf | Inf | -0.9137 | -0.9137 | 0.0000 | 0.3813 |
| MCF 10A-H2B-mCherry | Taxol | 26.31 | 11.8 | 0.0016 | 0.0039 | -0.9101 | -0.9124 | 1.2276 | 0.9742 |
| MCF 10A-H2B-mCherry | Taxol | 24.34 | 11.8 | 0.002 | 0.0046 | -0.9432 | -0.9101 | 1.2484 | 0.9442 |
| MCF 10A-H2B-mCherry | Alpelisib | 80.50 | 11.8 | Inf | Inf | -0.7248 | -0.9024 | 0.5606 | 0.5652 |
| MCF 10A-H2B-mCherry | Dasatinib | 20.40 | 11.8 | 0.3216 | 14.6959 | 0.0500 | -0.8825 | 0.3178 | 0.4415 |
| MCF 10A-H2B-mCherry | Taxol | 14.50 | 11.8 | 0.0054 | 0.0111 | -0.8917 | -0.8789 | 1.6037 | 0.7582 |
| MCF 10A-H2B-mCherry | Dasatinib | 72.62 | 11.8 | Inf | Inf | -0.6968 | -0.8679 | 2.5000 | 0.2828 |
| MCF 10A-H2B-mCherry | Taxol | 28.28 | 11.8 | 0.0013 | 0.003 | -0.8701 | -0.8390 | 1.2391 | 0.9847 |
| MCF 10A-H2B-mCherry | Taxol | 30.24 | 11.8 | 0.0011 | 0.0024 | -0.8135 | -0.8348 | 1.2978 | 1.0177 |
| MCF 10A-H2B-mCherry | Palbociclib | 80.50 | 11.8 | 6.7725 | 8.2243 | -0.3199 | -0.8211 | 5.0000 | 0.0725 |
| MCF 10A-H2B-mCherry | Palbociclib | 76.56 | 11.8 | 7.1386 | 8.822 | -0.1401 | -0.8206 | 5.0000 | 0.0720 |
| MCF 10A-H2B-mCherry | Neratinib | 66.21 | 12.8 | 0.4418 | 0.7084 | -0.7114 | -0.8082 | 3.1712 | 0.3995 |
| MCF 10A-H2B-mCherry | Palbociclib | 82.47 | 11.8 | 5.9596 | 7.8902 | -0.2712 | -0.8072 | 3.8956 | 0.0791 |
| MCF 10A-H2B-mCherry | Dasatinib | 74.59 | 11.8 | Inf | Inf | -0.7935 | -0.7935 | 0.0000 | 0.3297 |
| MCF 10A-H2B-mCherry | Alpelisib | 78.53 | 11.8 | Inf | Inf | -0.5687 | -0.7801 | 0.5348 | 0.5215 |