LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 44.04 | 11.8 | Inf | Inf | 0.8807 | 0.2777 | 0.1810 | 0.0312 |
| MCF 10A-H2B-mCherry | Palbociclib | 62.27 | 12.8 | Inf | Inf | 0.3703 | 0.3202 | 1.2436 | 0.0891 |
| MCF 10A-H2B-mCherry | Palbociclib | 14.50 | 11.8 | 0.1749 | 0.0968 | 0.2268 | 0.3503 | 2.9383 | 0.3639 |
| MCF 10A-H2B-mCherry | Trametinib | 22.37 | 11.8 | 0.0038 | 0.0015 | 0.2809 | 0.3571 | 1.7782 | 0.4868 |
| MCF 10A-H2B-mCherry | Alpelisib | 36.16 | 11.8 | Inf | Inf | 0.7081 | 0.3588 | 0.1341 | 0.0812 |
| MCF 10A-H2B-mCherry | Palbociclib | 66.21 | 12.8 | Inf | Inf | 0.3784 | 0.3627 | 2.5000 | 0.0744 |
| MCF 10A-H2B-mCherry | Trametinib | 20.40 | 11.8 | Inf | 0.0016 | 0.3724 | 0.4347 | 1.8504 | 0.4166 |
| MCF 10A-H2B-mCherry | Trametinib | 18.43 | 11.8 | Inf | 0.0022 | 0.3943 | 0.4937 | 2.5017 | 0.3567 |
| MCF 10A-H2B-mCherry | Trametinib | 16.47 | 11.8 | Inf | Inf | 0.4895 | 0.5143 | 0.2747 | 0.3240 |
| MCF 10A-H2B-mCherry | Alpelisib | 16.47 | 11.8 | Inf | Inf | 0.5437 | 0.5437 | 0.0000 | 0.1861 |
| MCF 10A-H2B-mCherry | Alpelisib | 22.37 | 11.8 | Inf | Inf | 0.5252 | 0.5693 | 2.5000 | 0.1619 |
| MCF 10A-H2B-mCherry | Alpelisib | 14.50 | 11.8 | Inf | Inf | 0.5830 | 0.5830 | 0.0000 | 0.1656 |
| MCF 10A-H2B-mCherry | Alpelisib | 20.40 | 11.8 | Inf | Inf | 0.5314 | 0.5864 | 2.4995 | 0.1792 |
| MCF 10A-H2B-mCherry | Alpelisib | 18.43 | 11.8 | Inf | Inf | 0.5222 | 0.6101 | 2.4994 | 0.1797 |
| MCF 10A-H2B-mCherry | Alpelisib | 70.65 | 11.8 | Inf | Inf | 0.4267 | 0.6197 | 0.6734 | 0.2143 |
| MCF 10A-H2B-mCherry | Neratinib | 86.41 | 11.8 | Inf | Inf | 0.6220 | 0.6220 | 0.0000 | 0.3526 |
| MCF 10A-H2B-mCherry | Trametinib | 14.50 | 11.8 | Inf | Inf | 0.6020 | 0.6432 | 0.3547 | 0.2812 |
| MCF 10A-H2B-mCherry | Alpelisib | 66.21 | 12.8 | Inf | Inf | 0.7208 | 0.7208 | 0.0000 | 0.0599 |
| MCF 10A-H2B-mCherry | Alpelisib | 68.68 | 11.8 | Inf | Inf | 0.5890 | 0.7519 | 2.5000 | 0.1166 |
| MCF 10A-H2B-mCherry | Neratinib | 88.39 | 11.8 | Inf | Inf | 0.8099 | 0.8099 | 0.0000 | 0.3692 |
| MCF 10A-H2B-mCherry | Alpelisib | 47.98 | 11.8 | Inf | Inf | 0.8928 | 0.8928 | 0.0000 | 0.0043 |
| MCF 10A-H2B-mCherry | Alpelisib | 49.95 | 11.8 | Inf | Inf | 0.9252 | 0.9252 | 0.0000 | -0.0030 |
| MCF 10A-H2B-mCherry | Alpelisib | 51.92 | 11.8 | Inf | Inf | 0.9806 | 0.9806 | 0.0000 | 0.0026 |
| MCF 10A-H2B-mCherry | Alpelisib | 53.89 | 11.8 | Inf | Inf | 0.9884 | 0.9884 | 0.0000 | 0.0083 |
| MCF 10A-H2B-mCherry | Alpelisib | 58.33 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0079 |