LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)

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Cell Small Molecule Time Point (hr) Time Interval (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Palbociclib 88.39 11.8
Inf
Inf
 0.1807 0.1415 2.5000 0.1081
MCF 10A-H2B-mCherry Palbociclib 68.68 11.8
Inf
Inf
 0.2001 0.1415 2.5000 0.1170
MCF 10A-H2B-mCherry Trametinib 80.50 11.8
Inf
Inf
 -0.0324 0.1443 2.5000 0.3980
MCF 10A-H2B-mCherry Trametinib 30.24 11.8
0.0032
0.0024
 0.2038 0.1467 1.4251 0.6040
MCF 10A-H2B-mCherry Trametinib 49.95 11.8
0.0169
0.0154
 0.0853 0.1488 2.3547 0.4333
MCF 10A-H2B-mCherry Vorinostat 86.41 11.8
Inf
Inf
 0.1733 0.1489 2.5000 0.2719
MCF 10A-H2B-mCherry Palbociclib 44.04 11.8
0.3482
0.3213
 0.0675 0.1504 2.8898 0.3203
MCF 10A-H2B-mCherry Trametinib 28.28 11.8
0.0024
0.0019
 0.1727 0.1684 1.4999 0.6108
MCF 10A-H2B-mCherry Neratinib 14.50 11.8
0.1014
0.0723
 0.1817 0.1723 1.2230 0.3790
MCF 10A-H2B-mCherry Trametinib 70.65 11.8
0.0304
0.028
 0.0121 0.1724 5.0000 0.3478
MCF 10A-H2B-mCherry Palbociclib 16.47 11.8
Inf
Inf
 0.1333 0.1764 0.4900 0.4113
MCF 10A-H2B-mCherry Trametinib 26.31 11.8
0.0024
0.0018
 0.1118 0.1831 1.6599 0.5994
MCF 10A-H2B-mCherry Neratinib 16.47 11.8
0.0475
0.0399
 0.1640 0.1862 2.9328 0.4268
MCF 10A-H2B-mCherry Vorinostat 82.47 11.8
Inf
Inf
 0.2104 0.1892 2.5000 0.2370
MCF 10A-H2B-mCherry Palbociclib 40.10 11.8
0.3048
0.2526
 0.0977 0.1916 2.9421 0.3204
MCF 10A-H2B-mCherry Vorinostat 76.56 11.8
Inf
Inf
 0.2240 0.1921 2.5000 0.2324
MCF 10A-H2B-mCherry Vorinostat 70.65 11.8
4.0002
3.6262
 0.0895 0.1990 4.9999 0.1728
MCF 10A-H2B-mCherry Palbociclib 64.24 12.8
Inf
Inf
 0.2311 0.2111 2.5000 0.0711
MCF 10A-H2B-mCherry Palbociclib 58.33 12.8
Inf
2.7842
 0.2336 0.2251 3.3390 0.1717
MCF 10A-H2B-mCherry Palbociclib 56.36 12.8
4.6212
2.9453
 0.2561 0.2318 2.3448 0.1793
MCF 10A-H2B-mCherry Palbociclib 70.65 11.8
Inf
Inf
 0.3868 0.2469 2.5000 0.0899
MCF 10A-H2B-mCherry Vorinostat 80.50 11.8
Inf
Inf
 0.2547 0.2547 0.0000 0.2783
MCF 10A-H2B-mCherry Alpelisib 72.62 11.8
Inf
Inf
 0.1179 0.2602 0.5184 0.2709
MCF 10A-H2B-mCherry Alpelisib 38.13 11.8
Inf
Inf
 0.7322 0.2688 0.1564 0.0791
MCF 10A-H2B-mCherry Trametinib 24.34 11.8
0.0023
0.0014
 0.1795 0.2762 1.8365 0.5496