LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)

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Cell Small Molecule Time Point (hr) Time Interval (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Trametinib 60.30 12.8
0.0236
0.0232
 0.0787 0.0863 5.0000 0.3806
MCF 10A-H2B-mCherry Trametinib 42.07 11.8
0.0098
0.0098
 0.0617 0.0867 3.1683 0.5169
MCF 10A-H2B-mCherry Trametinib 74.59 11.8
Inf
Inf
 0.0817 0.0886 2.5000 0.3756
MCF 10A-H2B-mCherry Vorinostat 88.39 11.8
Inf
Inf
 0.1389 0.0902 2.5000 0.4167
MCF 10A-H2B-mCherry Vorinostat 66.21 12.8
3.8725
3.7635
 0.0749 0.0914 5.0000 0.1148
MCF 10A-H2B-mCherry Trametinib 56.36 12.8
0.0217
0.0212
 0.0706 0.0936 4.0713 0.3913
MCF 10A-H2B-mCherry Palbociclib 72.62 11.8
Inf
Inf
 0.1477 0.0937 2.5000 0.1111
MCF 10A-H2B-mCherry Trametinib 53.89 11.8
0.0199
0.0196
 0.0785 0.0995 3.4830 0.4064
MCF 10A-H2B-mCherry Palbociclib 18.43 11.8
Inf
Inf
 0.0844 0.1016 0.4161 0.4274
MCF 10A-H2B-mCherry Palbociclib 51.92 11.8
1.9664
2.097
 0.0937 0.1019 3.0700 0.2349
MCF 10A-H2B-mCherry Vorinostat 78.53 11.8
Inf
Inf
 0.0626 0.1037 2.4991 0.2671
MCF 10A-H2B-mCherry Trametinib 72.62 11.8
0.0314
0.0301
 -0.0207 0.1090 5.0000 0.3790
MCF 10A-H2B-mCherry Trametinib 44.04 11.8
0.0109
0.0109
 0.0743 0.1124 3.2317 0.4865
MCF 10A-H2B-mCherry Trametinib 46.00 11.8
0.0114
0.0113
 0.0825 0.1163 3.1843 0.4779
MCF 10A-H2B-mCherry Trametinib 38.13 11.8
0.0074
0.0053
 0.1560 0.1209 1.2030 0.5462
MCF 10A-H2B-mCherry Trametinib 32.22 11.8
0.0041
0.003
 0.1270 0.1256 1.2096 0.5959
MCF 10A-H2B-mCherry Palbociclib 42.07 11.8
0.3232
0.3135
 0.0817 0.1262 2.8482 0.3335
MCF 10A-H2B-mCherry Trametinib 64.24 12.8
0.0312
0.0294
 0.0440 0.1264 5.0000 0.3304
MCF 10A-H2B-mCherry Trametinib 51.92 11.8
0.0198
0.0188
 0.0670 0.1281 2.9735 0.4126
MCF 10A-H2B-mCherry Trametinib 36.16 11.8
0.0058
0.004
 0.1620 0.1287 1.1729 0.5671
MCF 10A-H2B-mCherry Neratinib 18.43 11.8
0.0448
0.0413
 0.1418 0.1300 2.9533 0.4580
MCF 10A-H2B-mCherry Trametinib 47.98 11.8
0.0134
0.0129
 0.0552 0.1302 3.2813 0.4508
MCF 10A-H2B-mCherry Trametinib 34.19 11.8
0.0057
0.0039
 0.1750 0.1365 1.2451 0.5626
MCF 10A-H2B-mCherry Trametinib 66.21 12.8
0.0293
0.0275
 0.0599 0.1396 5.0000 0.3328
MCF 10A-H2B-mCherry Vorinostat 72.62 11.8
Inf
Inf
 0.1396 0.1396 0.0000 0.1845