LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 30.24 | 11.8 | Inf | Inf | 0.5895 | -0.1967 | 0.3776 | 0.1021 |
| MCF 10A-H2B-mCherry | Dasatinib | 18.43 | 11.8 | 0.3036 | 12.6517 | 0.0458 | -0.6348 | 0.3781 | 0.4299 |
| MCF 10A-H2B-mCherry | Neratinib | 72.62 | 11.8 | Inf | Inf | -0.6829 | -0.9987 | 0.4021 | 0.4642 |
| MCF 10A-H2B-mCherry | Dasatinib | 30.24 | 11.8 | 1.0071 | 14.9742 | -0.0381 | -1.0000 | 0.4085 | 0.3298 |
| MCF 10A-H2B-mCherry | Alpelisib | 76.56 | 11.8 | Inf | Inf | -0.3605 | -0.5430 | 0.4156 | 0.4223 |
| MCF 10A-H2B-mCherry | Palbociclib | 18.43 | 11.8 | Inf | Inf | 0.0844 | 0.1016 | 0.4161 | 0.4274 |
| MCF 10A-H2B-mCherry | Alpelisib | 84.44 | 11.8 | Inf | Inf | -0.6603 | -0.9436 | 0.4167 | 0.5697 |
| MCF 10A-H2B-mCherry | Alpelisib | 74.59 | 11.8 | Inf | Inf | -0.2722 | -0.3540 | 0.4280 | 0.3853 |
| MCF 10A-H2B-mCherry | Dasatinib | 36.16 | 11.8 | 1.1086 | 14.38 | -0.0457 | -1.0000 | 0.4301 | 0.3274 |
| MCF 10A-H2B-mCherry | Dasatinib | 38.13 | 11.8 | 1.2309 | 14.7989 | -0.0305 | -1.0000 | 0.4484 | 0.3159 |
| MCF 10A-H2B-mCherry | Neratinib | 76.56 | 11.8 | Inf | Inf | -0.6488 | -0.9900 | 0.4587 | 0.4979 |
| MCF 10A-H2B-mCherry | Dasatinib | 32.22 | 11.8 | 1.1811 | 12.756 | -0.0495 | -1.0000 | 0.4626 | 0.3081 |
| MCF 10A-H2B-mCherry | Alpelisib | 82.47 | 11.8 | Inf | Inf | -0.7155 | -0.9323 | 0.4722 | 0.5723 |
| MCF 10A-H2B-mCherry | Dasatinib | 34.19 | 11.8 | 1.228 | 11.8316 | -0.0560 | -1.0000 | 0.4857 | 0.3070 |
| MCF 10A-H2B-mCherry | Palbociclib | 16.47 | 11.8 | Inf | Inf | 0.1333 | 0.1764 | 0.4900 | 0.4113 |
| MCF 10A-H2B-mCherry | Alpelisib | 72.62 | 11.8 | Inf | Inf | 0.1179 | 0.2602 | 0.5184 | 0.2709 |
| MCF 10A-H2B-mCherry | Alpelisib | 78.53 | 11.8 | Inf | Inf | -0.5687 | -0.7801 | 0.5348 | 0.5215 |
| MCF 10A-H2B-mCherry | Palbociclib | 28.28 | 11.8 | 0.4036 | 8.1899 | 0.0432 | -0.3718 | 0.5514 | 0.3797 |
| MCF 10A-H2B-mCherry | Palbociclib | 34.19 | 11.8 | 0.6129 | 9.0593 | 0.0536 | -0.4395 | 0.5605 | 0.3342 |
| MCF 10A-H2B-mCherry | Alpelisib | 80.50 | 11.8 | Inf | Inf | -0.7248 | -0.9024 | 0.5606 | 0.5652 |
| MCF 10A-H2B-mCherry | Palbociclib | 36.16 | 11.8 | 0.5403 | 8.1051 | 0.0970 | -0.4551 | 0.5656 | 0.3518 |
| MCF 10A-H2B-mCherry | Etoposide | 26.31 | 11.8 | 0.487 | 1.8458 | -0.0111 | -0.3810 | 0.6094 | 0.3856 |
| MCF 10A-H2B-mCherry | Palbociclib | 32.22 | 11.8 | 0.515 | 8.8974 | 0.0517 | -0.4049 | 0.6119 | 0.3518 |
| MCF 10A-H2B-mCherry | Palbociclib | 30.24 | 11.8 | 0.4493 | 10.2532 | 0.0620 | -0.3916 | 0.6457 | 0.3642 |
| MCF 10A-H2B-mCherry | Neratinib | 74.59 | 11.8 | Inf | Inf | -0.7181 | -0.9989 | 0.6470 | 0.4952 |