LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 66.21 | 12.8 | Inf | Inf | 0.7208 | 0.7208 | 0.0000 | 0.0599 |
| MCF 10A-H2B-mCherry | Alpelisib | 36.16 | 11.8 | Inf | Inf | 0.7081 | 0.3588 | 0.1341 | 0.0812 |
| MCF 10A-H2B-mCherry | Alpelisib | 38.13 | 11.8 | Inf | Inf | 0.7322 | 0.2688 | 0.1564 | 0.0791 |
| MCF 10A-H2B-mCherry | Alpelisib | 44.04 | 11.8 | Inf | Inf | 0.8807 | 0.2777 | 0.1810 | 0.0312 |
| MCF 10A-H2B-mCherry | Alpelisib | 40.10 | 11.8 | Inf | Inf | 0.7745 | 0.0032 | 0.1903 | 0.0455 |
| MCF 10A-H2B-mCherry | Alpelisib | 42.07 | 11.8 | Inf | Inf | 0.7930 | -0.0552 | 0.2023 | 0.0423 |
| MCF 10A-H2B-mCherry | Alpelisib | 28.28 | 11.8 | Inf | Inf | 0.5629 | -0.2183 | 0.2154 | 0.1305 |
| MCF 10A-H2B-mCherry | Alpelisib | 46.00 | 11.8 | Inf | Inf | 0.8766 | 0.0250 | 0.2295 | 0.0292 |
| MCF 10A-H2B-mCherry | Alpelisib | 26.31 | 11.8 | Inf | Inf | 0.5498 | -0.1965 | 0.2406 | 0.1366 |
| MCF 10A-H2B-mCherry | Palbociclib | 22.37 | 11.8 | Inf | Inf | 0.0799 | 0.0010 | 0.2557 | 0.3981 |
| MCF 10A-H2B-mCherry | Trametinib | 16.47 | 11.8 | Inf | Inf | 0.4895 | 0.5143 | 0.2747 | 0.3240 |
| MCF 10A-H2B-mCherry | Palbociclib | 20.40 | 11.8 | Inf | Inf | 0.0818 | 0.0679 | 0.3009 | 0.4196 |
| MCF 10A-H2B-mCherry | Dasatinib | 16.47 | 11.8 | 0.2976 | 18.1565 | 0.0567 | -0.9754 | 0.3022 | 0.4478 |
| MCF 10A-H2B-mCherry | Alpelisib | 88.39 | 11.8 | Inf | Inf | -0.5245 | -0.9218 | 0.3023 | 0.5225 |
| MCF 10A-H2B-mCherry | Alpelisib | 24.34 | 11.8 | Inf | Inf | 0.5356 | -0.1945 | 0.3087 | 0.1509 |
| MCF 10A-H2B-mCherry | Dasatinib | 14.50 | 11.8 | 0.4949 | 9.8532 | 0.0959 | -0.7075 | 0.3145 | 0.4043 |
| MCF 10A-H2B-mCherry | Dasatinib | 20.40 | 11.8 | 0.3216 | 14.6959 | 0.0500 | -0.8825 | 0.3178 | 0.4415 |
| MCF 10A-H2B-mCherry | Dasatinib | 22.37 | 11.8 | 0.4115 | 15.4623 | 0.0244 | -1.0000 | 0.3218 | 0.4271 |
| MCF 10A-H2B-mCherry | Alpelisib | 32.22 | 11.8 | Inf | Inf | 0.6193 | -0.1765 | 0.3252 | 0.0795 |
| MCF 10A-H2B-mCherry | Dasatinib | 24.34 | 11.8 | 0.5409 | 14.19 | -0.0125 | -1.0000 | 0.3449 | 0.4043 |
| MCF 10A-H2B-mCherry | Dasatinib | 26.31 | 11.8 | 0.6274 | 15.1152 | -0.0263 | -1.0000 | 0.3476 | 0.3868 |
| MCF 10A-H2B-mCherry | Dasatinib | 28.28 | 11.8 | 0.7954 | 18.5915 | -0.0078 | -1.0000 | 0.3491 | 0.3618 |
| MCF 10A-H2B-mCherry | Trametinib | 14.50 | 11.8 | Inf | Inf | 0.6020 | 0.6432 | 0.3547 | 0.2812 |
| MCF 10A-H2B-mCherry | Alpelisib | 86.41 | 11.8 | Inf | Inf | -0.5643 | -0.9298 | 0.3611 | 0.5327 |
| MCF 10A-H2B-mCherry | Alpelisib | 34.19 | 11.8 | Inf | Inf | 0.6682 | -0.1536 | 0.3663 | 0.0626 |