LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Neratinib | 44.04 | 11.8 | 0.2075 | 0.2202 | -0.1442 | -0.0168 | 3.5213 | 0.3305 |
| MCF 10A-H2B-mCherry | Vorinostat | 49.95 | 11.8 | 1.7933 | 1.8862 | -0.0877 | -0.0193 | 3.5303 | 0.2968 |
| MCF 10A-H2B-mCherry | Neratinib | 46.00 | 11.8 | 0.2402 | 0.2637 | -0.1157 | -0.0213 | 3.5611 | 0.3155 |
| MCF 10A-H2B-mCherry | Neratinib | 53.89 | 11.8 | 0.3477 | 0.381 | -0.2664 | -0.1387 | 3.7292 | 0.2856 |
| MCF 10A-H2B-mCherry | Neratinib | 56.36 | 12.8 | 0.3409 | 0.3863 | -0.2782 | -0.2034 | 3.7838 | 0.2979 |
| MCF 10A-H2B-mCherry | Vorinostat | 51.92 | 11.8 | 2.1315 | 2.1375 | -0.0749 | 0.0429 | 3.8157 | 0.2783 |
| MCF 10A-H2B-mCherry | Palbociclib | 82.47 | 11.8 | 5.9596 | 7.8902 | -0.2712 | -0.8072 | 3.8956 | 0.0791 |
| MCF 10A-H2B-mCherry | Vorinostat | 60.30 | 12.8 | 3.0037 | 3.1465 | -0.0371 | -0.0795 | 3.9007 | 0.2301 |
| MCF 10A-H2B-mCherry | Palbociclib | 74.59 | 11.8 | 6.2258 | 8.3106 | -0.1752 | -0.7583 | 3.9365 | 0.1194 |
| MCF 10A-H2B-mCherry | Neratinib | 58.33 | 12.8 | 0.3234 | 0.371 | -0.3872 | -0.2928 | 3.9380 | 0.3253 |
| MCF 10A-H2B-mCherry | Trametinib | 56.36 | 12.8 | 0.0217 | 0.0212 | 0.0706 | 0.0936 | 4.0713 | 0.3913 |
| MCF 10A-H2B-mCherry | Neratinib | 68.68 | 11.8 | 0.3083 | 0.3924 | -0.7474 | -0.5509 | 4.1022 | 0.4356 |
| MCF 10A-H2B-mCherry | Vorinostat | 56.36 | 12.8 | 2.7127 | 2.6256 | -0.1112 | 0.0745 | 4.1340 | 0.2855 |
| MCF 10A-H2B-mCherry | Vorinostat | 58.33 | 12.8 | 3.121 | 3.2846 | -0.0803 | -0.0654 | 4.1663 | 0.2100 |
| MCF 10A-H2B-mCherry | Vorinostat | 53.89 | 11.8 | 2.3205 | 2.3162 | -0.0685 | 0.0560 | 4.1745 | 0.3126 |
| MCF 10A-H2B-mCherry | Etoposide | 80.50 | 11.8 | 0.4604 | 0.5628 | -0.5825 | -0.5212 | 4.2963 | 0.6204 |
| MCF 10A-H2B-mCherry | Trametinib | 62.27 | 12.8 | 0.0255 | 0.0246 | 0.0151 | 0.0703 | 4.3386 | 0.3770 |
| MCF 10A-H2B-mCherry | Trametinib | 58.33 | 12.8 | 0.0222 | 0.0223 | 0.0302 | 0.0515 | 4.3444 | 0.4024 |
| MCF 10A-H2B-mCherry | Etoposide | 78.53 | 11.8 | 0.4167 | 0.4886 | -0.6198 | -0.4902 | 4.5677 | 0.6156 |
| MCF 10A-H2B-mCherry | Neratinib | 42.07 | 11.8 | 0.1778 | 0.1791 | -0.1480 | 0.0027 | 4.6136 | 0.3474 |
| MCF 10A-H2B-mCherry | Taxol | 76.56 | 11.8 | 0.0011 | 0.0012 | -0.1940 | -0.3600 | 4.9956 | 0.8032 |
| MCF 10A-H2B-mCherry | Taxol | 74.59 | 11.8 | 0.0011 | 0.0012 | -0.1346 | -0.2979 | 4.9959 | 0.7808 |
| MCF 10A-H2B-mCherry | Taxol | 78.53 | 11.8 | 0.0011 | 0.0012 | -0.4490 | -0.3760 | 4.9969 | 0.8513 |
| MCF 10A-H2B-mCherry | Taxol | 68.68 | 11.8 | 0.0011 | 0.0012 | -0.3052 | -0.4978 | 4.9979 | 0.9495 |
| MCF 10A-H2B-mCherry | Taxol | 80.50 | 11.8 | 0.0009 | 0.0011 | -0.4560 | -0.4969 | 4.9979 | 0.8957 |