LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Vorinostat | 64.24 | 12.8 | 3.8453 | 3.8311 | 0.0082 | 0.0174 | 5.0000 | 0.1712 |
| MCF 10A-H2B-mCherry | Palbociclib | 58.33 | 12.8 | Inf | 2.7842 | 0.2336 | 0.2251 | 3.3390 | 0.1717 |
| MCF 10A-H2B-mCherry | Vorinostat | 70.65 | 11.8 | 4.0002 | 3.6262 | 0.0895 | 0.1990 | 4.9999 | 0.1728 |
| MCF 10A-H2B-mCherry | Dasatinib | 49.95 | 11.8 | 2.5744 | 6.7152 | -0.1544 | -0.6110 | 2.8420 | 0.1745 |
| MCF 10A-H2B-mCherry | Dasatinib | 66.21 | 12.8 | Inf | Inf | -0.3392 | -0.7266 | 2.5000 | 0.1746 |
| MCF 10A-H2B-mCherry | Alpelisib | 20.40 | 11.8 | Inf | Inf | 0.5314 | 0.5864 | 2.4995 | 0.1792 |
| MCF 10A-H2B-mCherry | Palbociclib | 56.36 | 12.8 | 4.6212 | 2.9453 | 0.2561 | 0.2318 | 2.3448 | 0.1793 |
| MCF 10A-H2B-mCherry | Alpelisib | 18.43 | 11.8 | Inf | Inf | 0.5222 | 0.6101 | 2.4994 | 0.1797 |
| MCF 10A-H2B-mCherry | Vorinostat | 72.62 | 11.8 | Inf | Inf | 0.1396 | 0.1396 | 0.0000 | 0.1845 |
| MCF 10A-H2B-mCherry | Alpelisib | 16.47 | 11.8 | Inf | Inf | 0.5437 | 0.5437 | 0.0000 | 0.1861 |
| MCF 10A-H2B-mCherry | Dasatinib | 47.98 | 11.8 | 2.0992 | 7.4506 | -0.1158 | -0.5961 | 1.9728 | 0.1935 |
| MCF 10A-H2B-mCherry | Vorinostat | 58.33 | 12.8 | 3.121 | 3.2846 | -0.0803 | -0.0654 | 4.1663 | 0.2100 |
| MCF 10A-H2B-mCherry | Palbociclib | 53.89 | 11.8 | 3.0804 | 6.8008 | 0.0928 | -0.4511 | 1.5959 | 0.2138 |
| MCF 10A-H2B-mCherry | Alpelisib | 70.65 | 11.8 | Inf | Inf | 0.4267 | 0.6197 | 0.6734 | 0.2143 |
| MCF 10A-H2B-mCherry | Vorinostat | 74.59 | 11.8 | Inf | Inf | 0.0392 | 0.0407 | 2.5000 | 0.2224 |
| MCF 10A-H2B-mCherry | Vorinostat | 60.30 | 12.8 | 3.0037 | 3.1465 | -0.0371 | -0.0795 | 3.9007 | 0.2301 |
| MCF 10A-H2B-mCherry | Vorinostat | 76.56 | 11.8 | Inf | Inf | 0.2240 | 0.1921 | 2.5000 | 0.2324 |
| MCF 10A-H2B-mCherry | Palbociclib | 51.92 | 11.8 | 1.9664 | 2.097 | 0.0937 | 0.1019 | 3.0700 | 0.2349 |
| MCF 10A-H2B-mCherry | Vorinostat | 82.47 | 11.8 | Inf | Inf | 0.2104 | 0.1892 | 2.5000 | 0.2370 |
| MCF 10A-H2B-mCherry | Dasatinib | 68.68 | 11.8 | Inf | Inf | -0.4111 | -0.4111 | 0.0000 | 0.2388 |
| MCF 10A-H2B-mCherry | Dasatinib | 70.65 | 11.8 | Inf | Inf | -0.4702 | -0.7605 | 2.5000 | 0.2422 |
| MCF 10A-H2B-mCherry | Palbociclib | 49.95 | 11.8 | 1.5871 | 2.9544 | 0.1121 | -0.1626 | 2.7729 | 0.2429 |
| MCF 10A-H2B-mCherry | Etoposide | 14.50 | 11.8 | 1.8736 | 7.8032 | 0.0786 | -0.4739 | 1.6271 | 0.2461 |
| MCF 10A-H2B-mCherry | Dasatinib | 46.00 | 11.8 | 1.925 | 11.0714 | -0.0764 | -1.0000 | 0.7940 | 0.2467 |
| MCF 10A-H2B-mCherry | Dasatinib | 40.10 | 11.8 | 1.6021 | 11.394 | -0.0635 | -1.0000 | 0.6554 | 0.2648 |