LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Etoposide | 56.36 | 12.8 | 0.1038 | 0.1853 | -0.1609 | -0.2487 | 2.7472 | 0.5857 |
| MCF 10A-H2B-mCherry | Etoposide | 62.27 | 12.8 | Inf | Inf | -0.0470 | -0.0653 | 2.5000 | 0.5949 |
| MCF 10A-H2B-mCherry | Trametinib | 32.22 | 11.8 | 0.0041 | 0.003 | 0.1270 | 0.1256 | 1.2096 | 0.5959 |
| MCF 10A-H2B-mCherry | Trametinib | 26.31 | 11.8 | 0.0024 | 0.0018 | 0.1118 | 0.1831 | 1.6599 | 0.5994 |
| MCF 10A-H2B-mCherry | Trametinib | 30.24 | 11.8 | 0.0032 | 0.0024 | 0.2038 | 0.1467 | 1.4251 | 0.6040 |
| MCF 10A-H2B-mCherry | Etoposide | 64.24 | 12.8 | Inf | Inf | -0.1610 | -0.2439 | 2.5000 | 0.6044 |
| MCF 10A-H2B-mCherry | Trametinib | 28.28 | 11.8 | 0.0024 | 0.0019 | 0.1727 | 0.1684 | 1.4999 | 0.6108 |
| MCF 10A-H2B-mCherry | Etoposide | 60.30 | 12.8 | Inf | Inf | -0.0882 | -0.1344 | 2.5000 | 0.6136 |
| MCF 10A-H2B-mCherry | Etoposide | 78.53 | 11.8 | 0.4167 | 0.4886 | -0.6198 | -0.4902 | 4.5677 | 0.6156 |
| MCF 10A-H2B-mCherry | Etoposide | 76.56 | 11.8 | Inf | Inf | -0.5161 | -0.3658 | 2.5000 | 0.6176 |
| MCF 10A-H2B-mCherry | Etoposide | 80.50 | 11.8 | 0.4604 | 0.5628 | -0.5825 | -0.5212 | 4.2963 | 0.6204 |
| MCF 10A-H2B-mCherry | Etoposide | 72.62 | 11.8 | Inf | Inf | -0.4368 | -0.3631 | 2.5000 | 0.6217 |
| MCF 10A-H2B-mCherry | Taxol | 53.89 | 11.8 | Inf | Inf | 0.0000 | -0.1371 | 2.5000 | 0.6254 |
| MCF 10A-H2B-mCherry | Trametinib | 88.39 | 11.8 | Inf | Inf | 0.0264 | 0.0453 | 2.5000 | 0.6297 |
| MCF 10A-H2B-mCherry | Etoposide | 70.65 | 11.8 | 0.374 | 0.4184 | -0.4742 | -0.3943 | 5.0000 | 0.6342 |
| MCF 10A-H2B-mCherry | Taxol | 58.33 | 12.8 | Inf | Inf | -0.3263 | -0.3780 | 2.4987 | 0.6387 |
| MCF 10A-H2B-mCherry | Etoposide | 68.68 | 11.8 | Inf | Inf | -0.3486 | -0.3917 | 2.4998 | 0.6419 |
| MCF 10A-H2B-mCherry | Etoposide | 74.59 | 11.8 | Inf | Inf | -0.4921 | -0.3975 | 2.5000 | 0.6448 |
| MCF 10A-H2B-mCherry | Taxol | 56.36 | 12.8 | Inf | Inf | 0.0000 | -0.1380 | 2.5000 | 0.6797 |
| MCF 10A-H2B-mCherry | Taxol | 51.92 | 11.8 | 0.0007 | 0.0009 | 0.3959 | -0.1137 | 3.3858 | 0.6843 |
| MCF 10A-H2B-mCherry | Taxol | 49.95 | 11.8 | 0.0008 | 0.001 | 0.1595 | -0.2136 | 3.3339 | 0.7515 |
| MCF 10A-H2B-mCherry | Taxol | 14.50 | 11.8 | 0.0054 | 0.0111 | -0.8917 | -0.8789 | 1.6037 | 0.7582 |
| MCF 10A-H2B-mCherry | Taxol | 74.59 | 11.8 | 0.0011 | 0.0012 | -0.1346 | -0.2979 | 4.9959 | 0.7808 |
| MCF 10A-H2B-mCherry | Taxol | 76.56 | 11.8 | 0.0011 | 0.0012 | -0.1940 | -0.3600 | 4.9956 | 0.8032 |
| MCF 10A-H2B-mCherry | Taxol | 82.47 | 11.8 | 0.0008 | 0.0008 | -0.4992 | -0.3263 | 5.0000 | 0.8223 |