LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Etoposide | 49.95 | 11.8 | 0.148 | 0.2092 | -0.1610 | -0.1704 | 2.8308 | 0.5196 |
| MCF 10A-H2B-mCherry | Alpelisib | 78.53 | 11.8 | Inf | Inf | -0.5687 | -0.7801 | 0.5348 | 0.5215 |
| MCF 10A-H2B-mCherry | Alpelisib | 88.39 | 11.8 | Inf | Inf | -0.5245 | -0.9218 | 0.3023 | 0.5225 |
| MCF 10A-H2B-mCherry | Neratinib | 22.37 | 11.8 | 0.0309 | 0.0304 | -0.0400 | 0.0052 | 0.9627 | 0.5264 |
| MCF 10A-H2B-mCherry | Trametinib | 84.44 | 11.8 | Inf | Inf | 0.0511 | 0.0738 | 2.5000 | 0.5285 |
| MCF 10A-H2B-mCherry | Trametinib | 40.10 | 11.8 | 0.0085 | 0.008 | 0.0908 | 0.0817 | 1.8608 | 0.5296 |
| MCF 10A-H2B-mCherry | Alpelisib | 86.41 | 11.8 | Inf | Inf | -0.5643 | -0.9298 | 0.3611 | 0.5327 |
| MCF 10A-H2B-mCherry | Neratinib | 24.34 | 11.8 | 0.0284 | 0.0292 | -0.0594 | 0.0081 | 1.1327 | 0.5345 |
| MCF 10A-H2B-mCherry | Trametinib | 82.47 | 11.8 | Inf | Inf | -0.0247 | 0.0349 | 2.5000 | 0.5380 |
| MCF 10A-H2B-mCherry | Etoposide | 84.44 | 11.8 | 0.5033 | 0.6125 | -0.4705 | -0.4504 | 4.9982 | 0.5433 |
| MCF 10A-H2B-mCherry | Trametinib | 38.13 | 11.8 | 0.0074 | 0.0053 | 0.1560 | 0.1209 | 1.2030 | 0.5462 |
| MCF 10A-H2B-mCherry | Neratinib | 26.31 | 11.8 | 0.0294 | 0.0356 | -0.1394 | -0.0698 | 0.9337 | 0.5476 |
| MCF 10A-H2B-mCherry | Neratinib | 28.28 | 11.8 | 0.0367 | 0.0686 | -0.2186 | -0.2457 | 0.8189 | 0.5478 |
| MCF 10A-H2B-mCherry | Trametinib | 24.34 | 11.8 | 0.0023 | 0.0014 | 0.1795 | 0.2762 | 1.8365 | 0.5496 |
| MCF 10A-H2B-mCherry | Trametinib | 86.41 | 11.8 | Inf | Inf | -0.0396 | 0.0266 | 2.5000 | 0.5563 |
| MCF 10A-H2B-mCherry | Etoposide | 51.92 | 11.8 | 0.1156 | 0.1784 | -0.2132 | -0.1905 | 2.7864 | 0.5566 |
| MCF 10A-H2B-mCherry | Trametinib | 34.19 | 11.8 | 0.0057 | 0.0039 | 0.1750 | 0.1365 | 1.2451 | 0.5626 |
| MCF 10A-H2B-mCherry | Alpelisib | 80.50 | 11.8 | Inf | Inf | -0.7248 | -0.9024 | 0.5606 | 0.5652 |
| MCF 10A-H2B-mCherry | Trametinib | 36.16 | 11.8 | 0.0058 | 0.004 | 0.1620 | 0.1287 | 1.1729 | 0.5671 |
| MCF 10A-H2B-mCherry | Alpelisib | 84.44 | 11.8 | Inf | Inf | -0.6603 | -0.9436 | 0.4167 | 0.5697 |
| MCF 10A-H2B-mCherry | Alpelisib | 82.47 | 11.8 | Inf | Inf | -0.7155 | -0.9323 | 0.4722 | 0.5723 |
| MCF 10A-H2B-mCherry | Etoposide | 82.47 | 11.8 | Inf | Inf | -0.6109 | -0.3921 | 2.5000 | 0.5753 |
| MCF 10A-H2B-mCherry | Etoposide | 66.21 | 12.8 | Inf | Inf | -0.2675 | -0.3004 | 2.4999 | 0.5759 |
| MCF 10A-H2B-mCherry | Etoposide | 53.89 | 11.8 | 0.105 | 0.27 | -0.2088 | -0.3323 | 2.6882 | 0.5777 |
| MCF 10A-H2B-mCherry | Etoposide | 58.33 | 12.8 | 0.08 | 1.0748 | -0.1876 | -0.5621 | 2.6279 | 0.5816 |