LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)

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Cell Small Molecule Time Point (hr) Time Interval (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Taxol 24.34 11.8
0.002
0.0046
 -0.9432 -0.9101 1.2484 0.9442
MCF 10A-H2B-mCherry Taxol 22.37 11.8
0.0022
0.0052
 -0.9405 -0.9510 1.3001 0.9473
MCF 10A-H2B-mCherry Trametinib 24.34 11.8
0.0023
0.0014
 0.1795 0.2762 1.8365 0.5496
MCF 10A-H2B-mCherry Trametinib 28.28 11.8
0.0024
0.0019
 0.1727 0.1684 1.4999 0.6108
MCF 10A-H2B-mCherry Trametinib 26.31 11.8
0.0024
0.0018
 0.1118 0.1831 1.6599 0.5994
MCF 10A-H2B-mCherry Taxol 20.40 11.8
0.0027
0.0057
 -0.9423 -0.9486 1.4238 0.9269
MCF 10A-H2B-mCherry Taxol 18.43 11.8
0.003
0.0066
 -0.9335 -0.9228 1.4098 0.8755
MCF 10A-H2B-mCherry Trametinib 30.24 11.8
0.0032
0.0024
 0.2038 0.1467 1.4251 0.6040
MCF 10A-H2B-mCherry Taxol 16.47 11.8
0.0034
0.0083
 -0.9391 -0.9437 1.3190 0.8401
MCF 10A-H2B-mCherry Trametinib 22.37 11.8
0.0038
0.0015
 0.2809 0.3571 1.7782 0.4868
MCF 10A-H2B-mCherry Trametinib 32.22 11.8
0.0041
0.003
 0.1270 0.1256 1.2096 0.5959
MCF 10A-H2B-mCherry Taxol 14.50 11.8
0.0054
0.0111
 -0.8917 -0.8789 1.6037 0.7582
MCF 10A-H2B-mCherry Trametinib 34.19 11.8
0.0057
0.0039
 0.1750 0.1365 1.2451 0.5626
MCF 10A-H2B-mCherry Trametinib 36.16 11.8
0.0058
0.004
 0.1620 0.1287 1.1729 0.5671
MCF 10A-H2B-mCherry Trametinib 38.13 11.8
0.0074
0.0053
 0.1560 0.1209 1.2030 0.5462
MCF 10A-H2B-mCherry Trametinib 40.10 11.8
0.0085
0.008
 0.0908 0.0817 1.8608 0.5296
MCF 10A-H2B-mCherry Trametinib 42.07 11.8
0.0098
0.0098
 0.0617 0.0867 3.1683 0.5169
MCF 10A-H2B-mCherry Trametinib 44.04 11.8
0.0109
0.0109
 0.0743 0.1124 3.2317 0.4865
MCF 10A-H2B-mCherry Trametinib 46.00 11.8
0.0114
0.0113
 0.0825 0.1163 3.1843 0.4779
MCF 10A-H2B-mCherry Trametinib 47.98 11.8
0.0134
0.0129
 0.0552 0.1302 3.2813 0.4508
MCF 10A-H2B-mCherry Trametinib 49.95 11.8
0.0169
0.0154
 0.0853 0.1488 2.3547 0.4333
MCF 10A-H2B-mCherry Trametinib 51.92 11.8
0.0198
0.0188
 0.0670 0.1281 2.9735 0.4126
MCF 10A-H2B-mCherry Trametinib 53.89 11.8
0.0199
0.0196
 0.0785 0.0995 3.4830 0.4064
MCF 10A-H2B-mCherry Trametinib 56.36 12.8
0.0217
0.0212
 0.0706 0.0936 4.0713 0.3913
MCF 10A-H2B-mCherry Trametinib 58.33 12.8
0.0222
0.0223
 0.0302 0.0515 4.3444 0.4024