LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Palbociclib | 20.40 | 11.8 | Inf | Inf | 0.0818 | 0.0679 | 0.3009 | 0.4196 |
| MCF 10A-H2B-mCherry | Palbociclib | 18.43 | 11.8 | Inf | Inf | 0.0844 | 0.1016 | 0.4161 | 0.4274 |
| MCF 10A-H2B-mCherry | Palbociclib | 16.47 | 11.8 | Inf | Inf | 0.1333 | 0.1764 | 0.4900 | 0.4113 |
| MCF 10A-H2B-mCherry | Neratinib | 88.39 | 11.8 | Inf | Inf | 0.8099 | 0.8099 | 0.0000 | 0.3692 |
| MCF 10A-H2B-mCherry | Neratinib | 86.41 | 11.8 | Inf | Inf | 0.6220 | 0.6220 | 0.0000 | 0.3526 |
| MCF 10A-H2B-mCherry | Palbociclib | 58.33 | 12.8 | Inf | 2.7842 | 0.2336 | 0.2251 | 3.3390 | 0.1717 |
| MCF 10A-H2B-mCherry | Palbociclib | 62.27 | 12.8 | Inf | Inf | 0.3703 | 0.3202 | 1.2436 | 0.0891 |
| MCF 10A-H2B-mCherry | Palbociclib | 64.24 | 12.8 | Inf | Inf | 0.2311 | 0.2111 | 2.5000 | 0.0711 |
| MCF 10A-H2B-mCherry | Palbociclib | 66.21 | 12.8 | Inf | Inf | 0.3784 | 0.3627 | 2.5000 | 0.0744 |
| MCF 10A-H2B-mCherry | Palbociclib | 68.68 | 11.8 | Inf | Inf | 0.2001 | 0.1415 | 2.5000 | 0.1170 |
| MCF 10A-H2B-mCherry | Palbociclib | 70.65 | 11.8 | Inf | Inf | 0.3868 | 0.2469 | 2.5000 | 0.0899 |
| MCF 10A-H2B-mCherry | Palbociclib | 72.62 | 11.8 | Inf | Inf | 0.1477 | 0.0937 | 2.5000 | 0.1111 |
| MCF 10A-H2B-mCherry | Palbociclib | 86.41 | 11.8 | Inf | Inf | 0.2113 | -0.0813 | 2.5000 | 0.0375 |
| MCF 10A-H2B-mCherry | Palbociclib | 88.39 | 11.8 | Inf | Inf | 0.1807 | 0.1415 | 2.5000 | 0.1081 |
| MCF 10A-H2B-mCherry | Neratinib | 84.44 | 11.8 | Inf | Inf | -0.2686 | -0.2686 | 0.0000 | 0.4519 |
| MCF 10A-H2B-mCherry | Neratinib | 82.47 | 11.8 | Inf | Inf | -0.2038 | -0.2038 | 0.0000 | 0.4483 |
| MCF 10A-H2B-mCherry | Neratinib | 80.50 | 11.8 | Inf | Inf | -0.3030 | -0.3030 | 0.0000 | 0.4783 |
| MCF 10A-H2B-mCherry | Neratinib | 78.53 | 11.8 | Inf | Inf | -0.7553 | -0.9963 | 1.0525 | 0.4438 |
| MCF 10A-H2B-mCherry | Neratinib | 76.56 | 11.8 | Inf | Inf | -0.6488 | -0.9900 | 0.4587 | 0.4979 |
| MCF 10A-H2B-mCherry | Neratinib | 74.59 | 11.8 | Inf | Inf | -0.7181 | -0.9989 | 0.6470 | 0.4952 |
| MCF 10A-H2B-mCherry | Neratinib | 72.62 | 11.8 | Inf | Inf | -0.6829 | -0.9987 | 0.4021 | 0.4642 |
| MCF 10A-H2B-mCherry | Etoposide | 82.47 | 11.8 | Inf | Inf | -0.6109 | -0.3921 | 2.5000 | 0.5753 |
| MCF 10A-H2B-mCherry | Etoposide | 76.56 | 11.8 | Inf | Inf | -0.5161 | -0.3658 | 2.5000 | 0.6176 |
| MCF 10A-H2B-mCherry | Etoposide | 74.59 | 11.8 | Inf | Inf | -0.4921 | -0.3975 | 2.5000 | 0.6448 |
| MCF 10A-H2B-mCherry | Etoposide | 72.62 | 11.8 | Inf | Inf | -0.4368 | -0.3631 | 2.5000 | 0.6217 |